RTP2 (Receptor Transporter Protein 2)
A gene encoding a chaperone protein involved in cell surface trafficking of olfactory and taste receptors.
Gene Information Card
| Symbol | RTP2 |
|---|---|
| Full Name | Receptor Transporter Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.3 |
| NCBI Gene ID | 344657 ncbi.nlm.nih.gov/gene/344657 |
| Ensembl ID | ENSG00000163877 |
| UniProt ID | Q5QGT7 |
| OMIM ID | 618854 |
| HGNC ID | 21386 |
| Aliases | RTP, RTP2A, FLJ22662 |
Description
RTP2 (Receptor Transporter Protein 2) encodes a member of the receptor transporter protein family. This protein functions as a chaperone that facilitates the cell surface expression of olfactory receptors and certain taste receptors (e.g., TAS2R bitter taste receptors). It is specifically expressed in olfactory epithelium and taste buds, playing a critical role in chemosensory signal transduction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Age-related olfactory loss | Reduced RTP2 expression may impair olfactory receptor trafficking | PMID: 23027930 |
| Bitter taste perception variation | RTP2 polymorphisms affect TAS2R cell surface expression | PMID: 21746835 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory epithelium | 12.5 | High |
| Tongue (taste buds) | 8.3 | Medium |
| Testis | 1.2 | Low |
| Brain (cortex) | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low endogenous expression |
| Hela | 0.3 | Not detected |
| Olfactory sensory neurons (primary) | 15.2 | High |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | 0.01% (gnomAD) | Unknown functional effect |
| c.520G>A (p.Gly174Ser) | Missense | 0.005% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Olfactory signaling pathway (Reactome: R-HSA-381753)
• GPCR ligand binding (Reactome: R-HSA-500792)
Protein Summary
RTP2 is a 25.5 kDa transmembrane protein localized to the endoplasmic reticulum and Golgi. It acts as a selective chaperone for olfactory receptors (ORs) and some taste receptors, promoting their proper folding, exit from the ER, and trafficking to the plasma membrane. RTP2 does not bind ligands directly but is essential for functional chemoreceptor expression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RTP2 Knockout HEK293 Cell Line | EDJ-KQ15144 | Human | 344892 | Details Get a Quote |
| RTP2 Knockout HeLa Cell Line | EDJ-KQ59780 | Human | 344892 | Details Get a Quote |
| RTP2 Knockout A-549 Cell Line | EDJ-KQ68248 | Human | 344892 | Details Get a Quote |
| RTP2 Knockout HCT 116 Cell Line | EDJ-KQ76625 | Human | 344892 | Details Get a Quote |
