RTN4RL2 Gene - Reticulon 4 Receptor Like 2
Comprehensive genomic and functional analysis of RTN4RL2, a member of the reticulon 4 receptor family involved in axonal growth inhibition and neural development.
Gene Information Card
| Symbol | RTN4RL2 |
|---|---|
| Full Name | Reticulon 4 Receptor Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.2 |
| NCBI Gene ID | 349667 ncbi.nlm.nih.gov/gene/349667 |
| Ensembl ID | ENSG00000186907 |
| UniProt ID | Q86UN2 |
| OMIM ID | 610850 |
| HGNC ID | 21394 |
| Aliases | NGRH2, Nogo receptor-like 2 |
Description
RTN4RL2 (Reticulon 4 Receptor Like 2) is a protein-coding gene that encodes a member of the reticulon 4 receptor family. The encoded protein is a glycosylphosphatidylinositol (GPI)-anchored receptor that binds Nogo-66 and other myelin-associated inhibitors, mediating axonal growth inhibition and playing a role in neural development and regeneration. It is predominantly expressed in the nervous system.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Potential involvement in neural connectivity; altered expression may contribute to synaptic dysfunction. | Limited; expression studies in postmortem brain tissue (NCBI Gene, OMIM) |
| Multiple Sclerosis | May influence axonal regeneration failure due to myelin inhibition. | Inferred from functional homology; not directly validated in large cohorts (UniProt) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Spinal cord | 8.3 | Medium |
| Testis | 2.1 | Low |
| Adrenal gland | 1.5 | Low |
| Liver | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 5.8 | Neuronal model |
| U-87 MG (glioblastoma) | 3.2 | Glial model |
| HEK293 (embryonic kidney) | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown; predicted benign (ClinVar) |
| c.1024G>A (p.Val342Met) | Missense | <0.01% | Unknown; predicted benign (ClinVar) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • receptor activity (GO:0004872) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) | • negative regulation of neuron projection development (GO:0010976) |
| • anchored component of membrane (GO:0031225) |
Pathways
• Nogo receptor signaling (R-HSA-193697)
• Axon guidance (R-HSA-422475)
Protein Summary
The RTN4RL2 protein (UniProt Q86UN2) is a 420-amino acid GPI-anchored receptor with a signal peptide and a conserved Nogo receptor domain. It localizes to the plasma membrane and binds myelin-associated inhibitors (e.g., Nogo-66, MAG, OMgp) to inhibit axonal growth. It is involved in neural development and regeneration, and its expression is enriched in the central nervous system.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RTN4RL2 Knockout HEK293 Cell Line | EDJ-KQ15143 | Human | 349667 | Details Get a Quote |
| RTN4RL2 Knockout A-549 Cell Line | EDJ-KQ45742 | Human | 349667 | Details Get a Quote |
| RTN4RL2 Knockout HCT 116 Cell Line | EDJ-KQ45743 | Human | 349667 | Details Get a Quote |
| RTN4RL2 Knockout HeLa Cell Line | EDJ-KQ59847 | Human | 349667 | Details Get a Quote |
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