RPL41: Ribosomal Protein L41 – A Key Component of the 60S Ribosomal Subunit
Comprehensive genomic and proteomic overview of RPL41, including gene structure, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | RPL41 |
|---|---|
| Full Name | Ribosomal Protein L41 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q13.2 |
| NCBI Gene ID | 6171 ncbi.nlm.nih.gov/gene/6171 |
| Ensembl ID | ENSG00000174437 |
| UniProt ID | P62945 |
| OMIM ID | 604175 |
| HGNC ID | 10365 |
| Aliases | L41, MGC72003 |
Description
RPL41 encodes a component of the 60S ribosomal subunit. The protein belongs to the L41E family of ribosomal proteins and is involved in translation initiation and elongation. It is one of the smallest ribosomal proteins and has been implicated in cellular stress responses and tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered RPL41 expression may affect ribosome biogenesis and translation fidelity, contributing to tumor progression. | PMID: 25605274 |
| Breast Cancer | RPL41 downregulation is associated with poor prognosis and may promote metastasis via translational reprogramming. | PMID: 29395067 |
| Hepatocellular Carcinoma | RPL41 mutations and reduced expression correlate with increased proliferation and invasion. | COSMIC ID: RPL41 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.8 | Medium |
| Heart | 8.2 | Low |
| Brain | 6.1 | Low |
| Testis | 15.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | High expression |
| HeLa | 11.5 | Medium expression |
| HepG2 | 13.0 | High expression |
| MCF7 | 9.8 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94C>T (p.Arg32Cys) | Missense | 0.02% | Altered protein stability and ribosome assembly |
| c.128_129insA (p.Glu44Glufs*3) | Frameshift | <0.01% | Loss of function; truncated protein |
| c.55G>A (p.Gly19Ser) | Missense | 0.01% | Reduced translational activity |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations lead to truncated or absent protein, impairing ribosome function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Missense mutations may produce a defective protein that interferes with wild-type ribosome assembly.
View complete mutation data：
Gene Ontology (GO)
| • structural constituent of ribosome (GO:0003735) | • translation (GO:0006412) |
| • ribosome (GO:0005840) | • cytoplasm (GO:0005737) |
Pathways
• Eukaryotic Translation Initiation (KEGG: hsa03010)
• Ribosome (KEGG: hsa03010)
Protein Summary
Ribosomal protein L41 is a small basic protein (25 amino acids) that binds to the 60S ribosomal subunit. It is essential for ribosome assembly and translation efficiency. Post-translational modifications include acetylation and phosphorylation, which modulate its function. RPL41 is highly conserved across eukaryotes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RPL41 Knockout HEK293 Cell Line | EDJ-KQ50587 | Human | 6171 | Details Get a Quote |
| RPL41 Knockout HeLa Cell Line | EDJ-KQ54355 | Human | 6171 | Details Get a Quote |
| RPL41 Knockout A-549 Cell Line | EDJ-KQ62851 | Human | 6171 | Details Get a Quote |
| RPL41 Knockout HCT 116 Cell Line | EDJ-KQ71317 | Human | 6171 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
