RPL34: Ribosomal Protein L34
A core component of the large ribosomal subunit involved in protein synthesis and implicated in cancer and developmental disorders.
Gene Information Card
| Symbol | RPL34 |
|---|---|
| Full Name | Ribosomal Protein L34 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q25 |
| NCBI Gene ID | 6164 ncbi.nlm.nih.gov/gene/6164 |
| Ensembl ID | ENSG00000109475 |
| UniProt ID | P49207 |
| OMIM ID | 617325 |
| HGNC ID | 10351 |
| Aliases | L34, eL34, MGC117267 |
Description
RPL34 encodes ribosomal protein L34, a component of the 60S large ribosomal subunit. This protein is involved in the initiation and elongation phases of protein synthesis. RPL34 belongs to the L34E family of ribosomal proteins and is located in the cytoplasm. The gene is highly conserved across eukaryotes. Overexpression or mutations of RPL34 have been linked to various cancers, including colorectal, gastric, and hepatocellular carcinoma, suggesting a role beyond canonical translation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of RPL34 promotes cell proliferation and invasion via upregulation of cyclin D1 and MMP-9. | PMID: 27557510 |
| Gastric Cancer | RPL34 is upregulated and correlates with poor prognosis; knockdown reduces cell growth and induces apoptosis. | PMID: 29393407 |
| Hepatocellular Carcinoma | RPL34 overexpression enhances tumor growth and metastasis through PI3K/AKT signaling. | PMID: 30343334 |
| Ribosomopathy (general) | Mutations in ribosomal proteins can cause tissue-specific disorders; RPL34 variants are rare but may contribute to Diamond-Blackfan anemia-like phenotypes. | PMID: 24675556 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Lymph node | 22.3 | High |
| Bone marrow | 20.1 | High |
| Brain | 12.4 | Medium |
| Liver | 10.8 | Medium |
| Heart | 8.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 25.0 | High expression in embryonic kidney cells |
| HeLa | 22.3 | High expression in cervical cancer cells |
| HepG2 | 19.7 | High expression in liver cancer cells |
| K562 | 18.5 | High expression in leukemia cells |
| MCF7 | 15.2 | Medium expression in breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.95A>G (p.Gln32Arg) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.124C>T (p.Arg42Cys) | Missense | <0.01% | Unknown; predicted damaging by PolyPhen-2 |
| c.201_202insA (p.Glu68Argfs*12) | Frameshift | <0.01% | Loss of function; truncation of protein |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.201_202insA) lead to premature stop codons and truncated protein, likely causing haploinsufficiency.
Gain of Function (GOF)
Not well documented; overexpression in cancers suggests possible gain-of-function through increased translation of oncogenic mRNAs.
Dominant Negative (DN)
No evidence currently available for dominant-negative effects of RPL34 mutations.
View complete mutation data：
Gene Ontology (GO)
| • structural constituent of ribosome (GO:0003735) | • translation (GO:0006412) |
| • cytosolic large ribosomal subunit (GO:0022625) | • cytoplasmic translation (GO:0002181) |
Pathways
• KEGG: hsa03010 - Ribosome
• Reactome: R-HSA-156902 - Peptide chain elongation
• Reactome: R-HSA-72766 - Translation
Protein Summary
Ribosomal protein L34 (RPL34) is a 117-amino-acid protein with a molecular weight of approximately 13.5 kDa. It is a component of the 60S large ribosomal subunit, where it contributes to the structural integrity and function of the ribosome. The protein contains a conserved L34E domain. RPL34 interacts with rRNA and other ribosomal proteins to facilitate peptide bond formation during translation. Beyond its canonical role, RPL34 has been implicated in cell cycle regulation, apoptosis, and tumorigenesis, likely through selective translation of specific mRNAs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RPL34 Knockout HEK293 Cell Line | EDJ-KQ50583 | Human | 6164 | Details Get a Quote |
| RPL34 Knockout HeLa Cell Line | EDJ-KQ54351 | Human | 6164 | Details Get a Quote |
| RPL34 Knockout A-549 Cell Line | EDJ-KQ62847 | Human | 6164 | Details Get a Quote |
| RPL34 Knockout HCT 116 Cell Line | EDJ-KQ71313 | Human | 6164 | Details Get a Quote |
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