RNF115 (Ring Finger Protein 115)
E3 ubiquitin-protein ligase involved in protein ubiquitination and cellular signaling
Gene Information Card
| Symbol | RNF115 |
|---|---|
| Full Name | Ring Finger Protein 115 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 27246 ncbi.nlm.nih.gov/gene/27246 |
| Ensembl ID | ENSG00000116285 |
| UniProt ID | Q9Y4L5 |
| OMIM ID | 616505 |
| HGNC ID | 16758 |
| Aliases | BCA2, ZNF364, RNF115 |
Description
RNF115 (ring finger protein 115) encodes an E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, playing roles in protein degradation, signal transduction, and cellular trafficking. It is also known as BCA2 (breast cancer-associated gene 2) and is implicated in breast cancer and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes ubiquitination and degradation of tumor suppressors, enhancing cell proliferation | PMID: 15314170; COSMIC |
| Prostate cancer | Altered expression linked to ubiquitin-mediated signaling | PMID: 21734258 |
| Ovarian cancer | Upregulation associated with poor prognosis | PMID: 25605274 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 | Medium |
| Ovary | 8.3 | Low |
| Prostate | 6.7 | Low |
| Testis | 15.2 | Medium |
| Lung | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.4 | High expression |
| HeLa (cervical cancer) | 9.8 | Moderate expression |
| PC3 (prostate cancer) | 7.2 | Low expression |
| A549 (lung cancer) | 4.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Unknown |
| c.100C>T | Nonsense | 0.005% | Loss of function |
| c.200_201insA | Frameshift | 0.002% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations predicted to truncate the protein, impairing E3 ligase activity.
Gain of Function (GOF)
Not reported in curated databases.
Dominant Negative (DN)
Not reported in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • zinc ion binding (GO:0008270) |
| • protein ubiquitination (GO:0016567) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
RNF115 is a 305-amino acid E3 ubiquitin ligase containing a RING-type zinc finger domain. It ubiquitinates substrates such as p53 and EGFR, influencing cell cycle, apoptosis, and receptor trafficking. Overexpression in breast cancer correlates with aggressive disease.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF115 Knockout HEK293 Cell Line | EDJ-KQ8727 | Human | 27246 | Details Get a Quote |
| RNF115 Knockout A-549 Cell Line | EDJ-KQ34968 | Human | 27246 | Details Get a Quote |
| RNF115 Knockout HCT 116 Cell Line | EDJ-KQ34969 | Human | 27246 | Details Get a Quote |
| RNF115 Knockout HeLa Cell Line | EDJ-KQ34970 | Human | 27246 | Details Get a Quote |
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