RNF11: Ring Finger Protein 11 - A Key Regulator of Ubiquitination and Signaling

Comprehensive genomic and proteomic analysis of RNF11, a RING finger E3 ubiquitin ligase implicated in cancer and immune signaling.

Gene Information Card

Symbol RNF11
Full Name Ring Finger Protein 11
Gene Type Protein coding
Chromosomal Location 1p32.3
NCBI Gene ID 26994 ncbi.nlm.nih.gov/gene/26994
Ensembl ID ENSG00000123091
UniProt ID Q9Y3C5
OMIM ID 612491
HGNC ID 10056
Aliases C2H2-150, CGI-123, FLJ10273, MGC1054, RING finger protein 11

Description

RNF11 (Ring Finger Protein 11) encodes a RING finger domain-containing protein that functions as an E3 ubiquitin ligase. It is involved in ubiquitination and proteasomal degradation of target proteins, playing a critical role in regulating signaling pathways such as NF-kB, TGF-beta, and EGFR. RNF11 is widely expressed and has been implicated in cancer progression, immune response, and cellular stress. The gene is located on chromosome 1p32.3 and is conserved across species.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
Breast Cancer RNF11 overexpression enhances NF-kB signaling and promotes cell proliferation; acts as a negative regulator of A20 (TNFAIP3). PMID: 19029909; COSMIC
Colorectal Cancer RNF11 is upregulated and associated with poor prognosis; modulates TGF-beta signaling via SMAD7 ubiquitination. PMID: 21573172; COSMIC
Prostate Cancer RNF11 expression correlates with tumor grade; involved in androgen receptor signaling. PMID: 22198284; COSMIC
Inflammatory Diseases RNF11 regulates NF-kB activation by targeting A20 for degradation, influencing chronic inflammation. PMID: 19029909; ClinVar

Expression Profile

Tissue Expression
Tissue nTPM level
Brain 12.5 Medium
Lung 8.3 Low
Liver 6.1 Low
Breast 15.2 Medium
Colon 18.7 Medium
Prostate 14.0 Medium
Kidney 9.8 Low
Testis 22.1 High
Cell Line Expression
Cell Line nTPM Notes
HEK293 16.5 Embryonic kidney cells; high expression
HeLa 14.2 Cervical cancer cells; moderate expression
MCF7 18.9 Breast cancer cells; high expression
A549 11.3 Lung cancer cells; moderate expression
HCT116 20.1 Colorectal cancer cells; high expression
Data source：Human Protein Atlas（proteinatlas.org）

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
c.215C>T (p.Pro72Leu) Missense <0.1% Unknown; reported in COSMIC
c.328G>A (p.Glu110Lys) Missense <0.1% Unknown; reported in COSMIC
c.454_455insA Frameshift <0.1% Loss of function; predicted
c.1A>G (p.Met1Val) Start loss <0.1% Loss of function; predicted
Mutation functional classification

Loss of Function (LOF)

Frameshift and start-loss mutations are predicted to result in loss of E3 ubiquitin ligase activity, impairing regulation of NF-kB and TGF-beta signaling.

Gain of Function (GOF)

No confirmed gain-of-function mutations reported in curated databases.

Dominant Negative (DN)

No dominant-negative mutations described in literature or databases.
View complete mutation data：
ClinVar：https://www.clinvar.com/gene/26994
COSMIC：https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=RNF11

Gene Ontology (GO)

• ubiquitin-protein transferase activity (GO:0004842) • protein binding (GO:0005515)
• zinc ion binding (GO:0008270) • protein ubiquitination (GO:0016567)
• positive regulation of I-kappaB kinase/NF-kB signaling (GO:0043123) • proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)
• cytoplasm (GO:0005737) • nucleus (GO:0005634)

Pathways

• NF-kB signaling pathway (Reactome: R-HSA-975827)
• TGF-beta signaling pathway (Reactome: R-HSA-170834)
• EGFR signaling pathway (Reactome: R-HSA-177929)
• Ubiquitin-mediated proteolysis (KEGG: hsa04120)

Protein Summary

RNF11 encodes a 154-amino acid protein with a RING finger domain at the N-terminus (residues 20-60) that confers E3 ubiquitin ligase activity. The protein interacts with A20 (TNFAIP3), SMAD7, and other signaling molecules to regulate ubiquitination and degradation. It is localized in the cytoplasm and nucleus, and its expression is induced by growth factors and stress. RNF11 is overexpressed in several cancers and is considered a potential therapeutic target.

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Related Products

Product name Cat.No. Species Gene ID
RNF114 Knockout HEK293 Cell Line EDJ-KQ2754 Human 55905 Details Get a Quote
RNF112 Knockout HEK293 Cell Line EDJ-KQ6089 Human 7732 Details Get a Quote
RNF11 Knockout HEK293 Cell Line EDJ-KQ8642 Human 26994 Details Get a Quote
RNF115 Knockout HEK293 Cell Line EDJ-KQ8727 Human 27246 Details Get a Quote
RNF113B Knockout HEK293 Cell Line EDJ-KQ9753 Human 140432 Details Get a Quote
RNF111 Knockout HEK293 Cell Line EDJ-KQ15095 Human 54778 Details Get a Quote
RNF115 Knockout A-549 Cell Line EDJ-KQ34968 Human 27246 Details Get a Quote
RNF115 Knockout HCT 116 Cell Line EDJ-KQ34969 Human 27246 Details Get a Quote
RNF115 Knockout HeLa Cell Line EDJ-KQ34970 Human 27246 Details Get a Quote
RNF114 Knockout A-549 Cell Line EDJ-KQ23646 Human 55905 Details Get a Quote
RNF114 Knockout HCT 116 Cell Line EDJ-KQ23647 Human 55905 Details Get a Quote
RNF114 Knockout HeLa Cell Line EDJ-KQ23648 Human 55905 Details Get a Quote
RNF11 Knockout A-549 Cell Line EDJ-KQ34812 Human 26994 Details Get a Quote
RNF11 Knockout HCT 116 Cell Line EDJ-KQ34813 Human 26994 Details Get a Quote
RNF11 Knockout HeLa Cell Line EDJ-KQ34814 Human 26994 Details Get a Quote
Displaying Records 1 To 15 Of 24 Records

Reference Databases

NCBI Gene https://www.ncbi.nlm.nih.gov/gene/26994
OMIM https://www.omim.org/entry/612491
HGNC https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10056
Ensembl https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123091
UniProt https://www.uniprot.org/uniprot/Q9Y3C5
ClinVar https://www.ncbi.nlm.nih.gov/clinvar/?term=RNF11
COSMIC https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=RNF11
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