RIPOR3 Gene
RIPOR Family Member 3
Gene Information Card
| Symbol | RIPOR3 |
|---|---|
| Full Name | RIPOR family member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 100130426 ncbi.nlm.nih.gov/gene/100130426 |
| Ensembl ID | ENSG00000205755 |
| UniProt ID | Q8N7B0 |
| OMIM ID | 619388 |
| HGNC ID | 37278 |
| Aliases | C16orf58, FAM65C, FLJ38725 |
Description
RIPOR3 (RIPOR family member 3) is a protein-coding gene located on chromosome 16p13.3. It belongs to the RIPOR family and is involved in cytoskeletal organization and cell polarity. The gene encodes a protein that interacts with Rho family GTPases and may play a role in cell migration and adhesion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.2 | Low |
| Lung | 6.1 | Low |
| Brain | 4.3 | Low |
| Heart | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Moderate expression |
| HeLa | 10.2 | Low expression |
| K562 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • cytoskeleton organization | • cell polarity |
| • protein binding |
Pathways
• Rho GTPase signaling
Protein Summary
The RIPOR3 protein is a member of the RIPOR family, characterized by a conserved RHO-binding domain. It localizes to the cytoplasm and is involved in regulating actin dynamics and cell shape. The protein may modulate Rho GTPase activity, influencing processes such as cell migration and adhesion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RIPOR3 Knockout HEK293 Cell Line | EDJ-KQ9824 | Human | 140876 | Details Get a Quote |
| RIPOR3 Knockout HeLa Cell Line | EDJ-KQ58468 | Human | 140876 | Details Get a Quote |
| RIPOR3 Knockout A-549 Cell Line | EDJ-KQ66955 | Human | 140876 | Details Get a Quote |
| RIPOR3 Knockout HCT 116 Cell Line | EDJ-KQ75356 | Human | 140876 | Details Get a Quote |
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