RGS10: Regulator of G Protein Signaling 10
A key modulator of G protein-coupled receptor signaling with roles in immune regulation, neuronal function, and cancer
Gene Information Card
| Symbol | RGS10 |
|---|---|
| Full Name | Regulator of G Protein Signaling 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q26.11 |
| NCBI Gene ID | 6001 ncbi.nlm.nih.gov/gene/6001 |
| Ensembl ID | ENSG00000148935 |
| UniProt ID | O43665 |
| OMIM ID | 602857 |
| HGNC ID | 9994 |
| Aliases | RGS10, dJ1068F16.3, RGS10A, RGS10B |
Description
RGS10 (Regulator of G Protein Signaling 10) is a member of the regulator of G protein signaling (RGS) family. It accelerates the GTPase activity of G protein alpha subunits, thereby terminating G protein-coupled receptor (GPCR) signaling. RGS10 is expressed in multiple tissues, with highest levels in the brain, immune cells, and heart. It plays critical roles in modulating neurotransmission, immune responses, and cell proliferation. Dysregulation of RGS10 has been implicated in cancer, neurodegenerative diseases, and inflammatory disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian cancer | RGS10 downregulation promotes chemoresistance and tumor progression via sustained GPCR signaling | PMID: 22926525; COSMIC |
| Breast cancer | Reduced RGS10 expression correlates with poor prognosis and increased metastasis | PMID: 25609832 |
| Parkinson's disease | RGS10 loss in microglia leads to neuroinflammation and dopaminergic neuron death | PMID: 22692725 |
| Multiple sclerosis | RGS10 deficiency exacerbates neuroinflammation in experimental autoimmune encephalomyelitis | PMID: 23966870 |
| Cardiac hypertrophy | RGS10 modulates Gq signaling; altered expression linked to hypertrophic responses | PMID: 17690171 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 12.5 | Medium |
| Heart | 9.8 | Medium |
| Lung | 6.2 | Low |
| Liver | 3.1 | Low |
| Spleen | 15.3 | High |
| Whole blood | 18.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | High expression |
| HeLa | 8.5 | Medium expression |
| K562 | 20.1 | Very high expression |
| SH-SY5Y | 11.3 | Medium expression |
| THP-1 | 22.6 | Very high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of start codon; predicted loss of function |
| c.124C>T (p.Arg42Cys) | Missense | <0.1% | Reduced GTPase accelerating activity |
| c.301G>A (p.Glu101Lys) | Missense | <0.1% | Unknown functional effect |
| c.424_425insA | Frameshift | <0.1% | Premature truncation; loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and start-loss mutations (e.g., c.424_425insA, c.1A>G) are predicted to cause loss of RGS10 protein function, impairing GPCR signal termination.
Gain of Function (GOF)
No gain-of-function mutations have been reported in RGS10.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for RGS10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• G alpha (i) signaling events (Reactome: R-HSA-418594)
• G alpha (q) signaling events (Reactome: R-HSA-416476)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
RGS10 is a 181-amino acid protein (20 kDa) belonging to the RGS family. It contains a conserved RGS domain that binds to activated Gα subunits and accelerates GTP hydrolysis, thereby switching off GPCR signaling. RGS10 is predominantly cytosolic but can translocate to the plasma membrane upon receptor activation. It is highly expressed in immune cells (especially microglia and macrophages) and neurons, where it regulates cytokine production, cell migration, and survival. Post-translational modifications include phosphorylation and palmitoylation, which modulate its stability and localization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RGS10 Knockout HEK293 Cell Line | EDJ-KQ4910 | Human | 6001 | Details Get a Quote |
| RGS10 Knockout A-549 Cell Line | EDJ-KQ29003 | Human | 6001 | Details Get a Quote |
| RGS10 Knockout HCT 116 Cell Line | EDJ-KQ29005 | Human | 6001 | Details Get a Quote |
| RGS10 Knockout HeLa Cell Line | EDJ-KQ29006 | Human | 6001 | Details Get a Quote |
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