REXO1
RNA Exonuclease 1 Homolog
Gene Information Card
| Symbol | REXO1 |
|---|---|
| Full Name | RNA Exonuclease 1 Homolog |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 57455 ncbi.nlm.nih.gov/gene/57455 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | Q8N1G1 |
| OMIM ID | 609614 |
| HGNC ID | 24660 |
| Aliases | REXO1, ELOABP1, REX1, REXO1L, CGI-114 |
Description
REXO1 (RNA exonuclease 1 homolog) encodes a 3'-5' exoribonuclease involved in RNA processing and degradation. The protein localizes to the nucleus and cytoplasm, and participates in the exosome-independent RNA decay pathway. REXO1 is conserved across eukaryotes and plays a role in ribosomal RNA maturation and turnover of non-coding RNAs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Brain | 4.7 | Low |
| Liver | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Moderate expression |
| HeLa | 7.4 | Low expression |
| K562 | 5.1 | Low expression |
| HepG2 | 4.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Likely loss of start codon |
| c.100C>T (p.Arg34Trp) | Missense | Rare | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • 3'-5' exoribonuclease activity | • RNA binding |
| • nucleus | • cytoplasm |
| • RNA catabolic process | • ribosome biogenesis |
Pathways
• RNA degradation
• Exosome-independent RNA decay
Protein Summary
REXO1 is a 3'-5' exoribonuclease that processes and degrades RNA substrates. It contains an N-terminal exonuclease domain and a C-terminal domain of unknown function. The protein is widely expressed at low levels, with highest abundance in testis. REXO1 interacts with RNA exosome components and is implicated in quality control of non-coding RNAs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| REXO1 Knockout HEK293 Cell Line | EDJ-KQ15040 | Human | 57455 | Details Get a Quote |
| REXO1 Knockout HeLa Cell Line | EDJ-KQ44336 | Human | 57455 | Details Get a Quote |
| REXO1 Knockout A-549 Cell Line | EDJ-KQ45590 | Human | 57455 | Details Get a Quote |
| REXO1 Knockout HCT 116 Cell Line | EDJ-KQ45591 | Human | 57455 | Details Get a Quote |
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