RETNLB (Resistin Like Beta)
A cytokine involved in inflammation, metabolism, and cancer
Gene Information Card
| Symbol | RETNLB |
|---|---|
| Full Name | Resistin Like Beta |
| Gene Type | protein-coding |
| Chromosomal Location | 3q13.13 |
| NCBI Gene ID | 84666 ncbi.nlm.nih.gov/gene/84666 |
| Ensembl ID | ENSG00000163515 |
| UniProt ID | Q9BQ08 |
| OMIM ID | 605660 |
| HGNC ID | 13528 |
| Aliases | FIZZ2, RELM-beta, HXCP2 |
Description
RETNLB (Resistin Like Beta) encodes a member of the resistin-like family of secreted proteins. The protein is predominantly expressed in the gastrointestinal tract and is involved in inflammatory responses, metabolic regulation, and tissue remodeling. It has been implicated in various cancers and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of RETNLB promotes tumor growth and metastasis through activation of PI3K/Akt and MAPK pathways. | PMID: 25605247 |
| Inflammatory Bowel Disease | RETNLB is upregulated in colonic mucosa of IBD patients and contributes to chronic inflammation via macrophage recruitment. | PMID: 16990168 |
| Asthma | RETNLB expression is elevated in airway epithelium and associated with Th2-type inflammation. | PMID: 16990168 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 48.2 | High |
| Small Intestine | 35.1 | High |
| Appendix | 30.5 | High |
| Stomach | 12.3 | Medium |
| Lung | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 52.0 | Colorectal adenocarcinoma cell line |
| HT-29 | 45.3 | Colorectal adenocarcinoma cell line |
| HCT 116 | 38.7 | Colorectal carcinoma cell line |
| A549 | 2.1 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | p.Met1Val; potential loss of start codon |
| c.100C>T | Missense | <0.1% | p.Arg34Cys; unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in RETNLB.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in RETNLB.
Dominant Negative (DN)
No dominant-negative mutations reported in RETNLB.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PI3K-Akt signaling pathway
• MAPK signaling pathway
• Cytokine-cytokine receptor interaction
Protein Summary
RETNLB encodes a 111-amino acid secreted protein (RELM-beta) characterized by a C-terminal cysteine-rich domain. It forms disulfide-linked homodimers and functions as a cytokine that modulates immune responses, particularly in the gastrointestinal tract. The protein is involved in promoting inflammation, cell proliferation, and tissue remodeling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RETNLB Knockout HEK293 Cell Line | EDJ-KQ10156 | Human | 84666 | Details Get a Quote |
| RETNLB Knockout HeLa Cell Line | EDJ-KQ57638 | Human | 84666 | Details Get a Quote |
| RETNLB Knockout A-549 Cell Line | EDJ-KQ66135 | Human | 84666 | Details Get a Quote |
| RETNLB Knockout HCT 116 Cell Line | EDJ-KQ74561 | Human | 84666 | Details Get a Quote |
