REG1B: Regenerating Family Member 1 Beta
A pancreatic secretory protein involved in tissue regeneration and inflammation
Gene Information Card
| Symbol | REG1B |
|---|---|
| Full Name | Regenerating Family Member 1 Beta |
| Gene Type | Protein coding |
| Chromosomal Location | 2p12 |
| NCBI Gene ID | 5968 ncbi.nlm.nih.gov/gene/5968 |
| Ensembl ID | ENSG00000172023 |
| UniProt ID | P48304 |
| OMIM ID | 167771 |
| HGNC ID | 9957 |
| Aliases | PSP, PTP, REG, REGI, REG-I, REG1, lithostathine 1 beta |
Description
REG1B encodes a member of the regenerating gene family, a group of small secretory proteins involved in pancreatic beta-cell regeneration, inflammation, and tissue repair. The protein is a pancreatic stone protein (lithostathine) that inhibits calcium carbonate crystal growth in pancreatic juice and may play a role in stress responses and cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Pancreatitis | Reduced REG1B expression may impair pancreatic stone inhibition, contributing to ductal obstruction and inflammation. | ClinVar, OMIM |
| Pancreatic Ductal Adenocarcinoma | Altered REG1B expression is observed in pancreatic cancer, potentially linked to tumor progression and stromal remodeling. | COSMIC, NCBI |
| Type 1 Diabetes | REG1B is implicated in beta-cell regeneration; autoantibodies against REG proteins have been reported in some patients. | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 1234.5 | High |
| Salivary Gland | 56.2 | Medium |
| Stomach | 12.3 | Low |
| Small Intestine | 8.7 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 45.6 | Pancreatic cancer cell line |
| MIA PaCa-2 | 32.1 | Pancreatic cancer cell line |
| HPAF-II | 28.9 | Pancreatic adenocarcinoma cell line |
| Capan-1 | 15.4 | Pancreatic cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown effect on protein function |
| c.123C>T | Synonymous | 0.02% | No predicted effect |
| c.456G>A | Missense | <0.01% | Reported in pancreatic cancer (COSMIC) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in REG1B.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Pancreatic secretion (KEGG: hsa04972)
• Regulation of insulin secretion (Reactome: R-HSA-422356)
Protein Summary
REG1B is a 166-amino acid secreted protein (UniProt P48304) belonging to the C-type lectin domain family. It is synthesized as a preproprotein and cleaved to form the mature lithostathine, which inhibits calcium carbonate precipitation in pancreatic juice. The protein also exhibits mitogenic activity on pancreatic beta-cells and may contribute to islet regeneration. Its expression is primarily restricted to the pancreas and salivary glands.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| REG1B Knockout HEK293 Cell Line | EDJ-KQ5647 | Human | 5968 | Details Get a Quote |
| REG1B Knockout HeLa Cell Line | EDJ-KQ54308 | Human | 5968 | Details Get a Quote |
| REG1B Knockout A-549 Cell Line | EDJ-KQ62802 | Human | 5968 | Details Get a Quote |
| REG1B Knockout HCT 116 Cell Line | EDJ-KQ71268 | Human | 5968 | Details Get a Quote |
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