RBM7: RNA Binding Motif Protein 7
A component of the nuclear exosome targeting complex involved in RNA processing and surveillance
Gene Information Card
| Symbol | RBM7 |
|---|---|
| Full Name | RNA Binding Motif Protein 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q21 |
| NCBI Gene ID | 10179 ncbi.nlm.nih.gov/gene/10179 |
| Ensembl ID | ENSG00000110395 |
| UniProt ID | Q9Y580 |
| OMIM ID | 612245 |
| HGNC ID | 9898 |
| Aliases | RNA-binding motif protein 7, ZCCHC22 |
Description
RBM7 encodes RNA binding motif protein 7, a component of the nuclear exosome targeting (NEXT) complex. The protein contains an RNA recognition motif (RRM) and a zinc finger domain, and is involved in the processing and degradation of a variety of RNA substrates, including small nuclear RNAs, small nucleolar RNAs, and cryptic unstable transcripts. RBM7 interacts with the exosome complex to facilitate RNA surveillance and turnover in the nucleus.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No direct evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.2 | Medium |
| Lung | 7.1 | Medium |
| Liver | 6.8 | Medium |
| Brain | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.3 | Cervical adenocarcinoma |
| HEK293 | 9.1 | Embryonic kidney |
| K562 | 8.7 | Chronic myeloid leukemia |
| A549 | 7.5 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No recurrent mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in disease context.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • nucleus (GO:0005634) |
| • nuclear exosome (RNase complex) (GO:0000176) | • RNA processing (GO:0006396) |
| • RNA catabolic process (GO:0006401) |
Pathways
• RNA degradation (KEGG hsa03018)
• Nuclear exosome targeting pathway (Reactome R-HSA-8953854)
Protein Summary
RBM7 is a 267-amino acid protein with a molecular weight of approximately 30 kDa. It contains an N-terminal RNA recognition motif (RRM) and a C-terminal zinc finger domain (CCHC type). RBM7 is a core component of the nuclear exosome targeting (NEXT) complex, where it recruits the exosome to specific RNA substrates for processing or degradation. The protein is ubiquitously expressed with higher levels in testis and spleen.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RBM7 Knockout HEK293 Cell Line | EDJ-KQ50936 | Human | 10179 | Details Get a Quote |
| RBM7 Knockout HeLa Cell Line | EDJ-KQ55337 | Human | 10179 | Details Get a Quote |
| RBM7 Knockout A-549 Cell Line | EDJ-KQ63817 | Human | 10179 | Details Get a Quote |
| RBM7 Knockout HCT 116 Cell Line | EDJ-KQ72279 | Human | 10179 | Details Get a Quote |
