RASSF2
Ras Association Domain Family Member 2
Gene Information Card
| Symbol | RASSF2 |
|---|---|
| Full Name | Ras association domain family member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 20p13 |
| NCBI Gene ID | 9770 ncbi.nlm.nih.gov/gene/9770 |
| Ensembl ID | ENSG00000101265 |
| UniProt ID | P50749 |
| OMIM ID | 609492 |
| HGNC ID | 9883 |
| Aliases | CENP-34, RASFADIN, RASSF3 |
Description
RASSF2 is a tumor suppressor gene encoding a protein that contains a Ras association domain. It is involved in Ras-dependent signaling pathways, promoting apoptosis and cell cycle arrest. Loss of RASSF2 expression due to promoter hypermethylation is frequently observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Promoter hypermethylation leading to loss of expression | NCBI Gene, COSMIC |
| Colorectal cancer | Epigenetic silencing via methylation | NCBI Gene, COSMIC |
| Breast cancer | Reduced expression associated with poor prognosis | NCBI Gene, COSMIC |
| Gastric cancer | Hypermethylation and loss of heterozygosity | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Lung | 8.1 | Medium |
| Colon | 6.4 | Medium |
| Breast | 4.7 | Low |
| Stomach | 7.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 3.5 | Low expression |
| HCT116 (colorectal cancer) | 2.1 | Low expression |
| MCF7 (breast cancer) | 1.8 | Low expression |
| HEK293 (embryonic kidney) | 12.4 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <1% | Unknown functional effect |
| c.205C>T | nonsense | <1% | Premature truncation, loss of function |
| c.340G>A | missense | <1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein; epigenetic silencing via promoter methylation.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • Ras GTPase binding | • protein binding |
| • apoptotic process | • negative regulation of cell cycle |
| • signal transduction |
Pathways
• Ras signaling pathway
• Apoptosis
• Cell cycle
Protein Summary
RASSF2 is a 326-amino acid protein containing a Ras association domain at the C-terminus. It interacts with Ras family GTPases and promotes apoptosis and cell cycle arrest. The protein is localized to the cytoplasm and nucleus, and its expression is frequently lost in cancers due to promoter hypermethylation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RASSF2 Knockout HEK293 Cell Line | EDJ-KQ6739 | Human | 9770 | Details Get a Quote |
| RASSF2 Knockout A-549 Cell Line | EDJ-KQ31138 | Human | 9770 | Details Get a Quote |
| RASSF2 Knockout HCT 116 Cell Line | EDJ-KQ29789 | Human | 9770 | Details Get a Quote |
| RASSF2 Knockout HeLa Cell Line | EDJ-KQ55252 | Human | 9770 | Details Get a Quote |
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