RASL11B
RAS-like family 11 member B
Gene Information Card
| Symbol | RASL11B |
|---|---|
| Full Name | RAS-like family 11 member B |
| Gene Type | protein-coding |
| Chromosomal Location | 4q12 |
| NCBI Gene ID | 65997 ncbi.nlm.nih.gov/gene/65997 |
| Ensembl ID | ENSG00000138668 |
| UniProt ID | Q9H9J7 |
| OMIM ID | 612908 |
| HGNC ID | 25706 |
| Aliases | FLJ10315, MGC131944 |
Description
RASL11B is a member of the RAS superfamily of small GTPases. It is involved in signal transduction pathways, potentially regulating cell growth and differentiation. The gene is located on chromosome 4q12 and encodes a protein of 196 amino acids.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Adipose tissue | 3.1 | Low |
| Brain | 2.8 | Low |
| Heart | 2.5 | Low |
| Liver | 1.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.0 | Moderate expression |
| HeLa | 3.5 | Moderate expression |
| K562 | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G (p.Ile41Met) | missense | <0.1% | Unknown functional impact |
| c.456C>T (p.Ser152=) | synonymous | <0.1% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding | • GTPase activity |
| • signal transduction | • intracellular signal transduction |
Pathways
• RAS signaling pathway
• MAPK signaling pathway
Protein Summary
RASL11B is a small GTPase that cycles between active GTP-bound and inactive GDP-bound states. It may modulate cell proliferation and differentiation through interaction with downstream effectors. The protein is predominantly expressed in testis and adipose tissue.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RASL11B Knockout HEK293 Cell Line | EDJ-KQ14996 | Human | 65997 | Details Get a Quote |
| RASL11B Knockout HeLa Cell Line | EDJ-KQ57114 | Human | 65997 | Details Get a Quote |
| RASL11B Knockout A-549 Cell Line | EDJ-KQ65627 | Human | 65997 | Details Get a Quote |
| RASL11B Knockout HCT 116 Cell Line | EDJ-KQ74051 | Human | 65997 | Details Get a Quote |
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