RASL11A Gene
RAS Like Family 11 Member A
Gene Information Card
| Symbol | RASL11A |
|---|---|
| Full Name | RAS Like Family 11 Member A |
| Gene Type | Protein coding |
| Chromosomal Location | 13q12.2 |
| NCBI Gene ID | 387496 ncbi.nlm.nih.gov/gene/387496 |
| Ensembl ID | ENSG00000175213 |
| UniProt ID | Q6TCH7 |
| OMIM ID | 612404 |
| HGNC ID | 25741 |
| Aliases | FLJ38973 |
Description
RASL11A is a member of the RAS superfamily of small GTPases. It encodes a protein that shares sequence similarity with RAS-like GTP-binding proteins. The gene is involved in signal transduction pathways, potentially regulating cell growth and differentiation. Expression is observed in various tissues, with notable levels in the prostate and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Potential role in tumor suppression; altered expression observed | COSMIC, NCBI Gene |
| Testicular germ cell tumors | Differential expression reported | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 8.6 | Medium |
| Testis | 6.2 | Medium |
| Adrenal gland | 4.1 | Low |
| Thyroid | 3.5 | Low |
| Lung | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 5.4 | Prostate cancer cell line |
| NTERA-2 (testicular) | 4.7 | Testicular germ cell tumor cell line |
| HEK 293 | 3.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.152A>G (p.Gln51Arg) | Missense | <0.1% | Unknown functional impact |
| c.214C>T (p.Arg72Trp) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding | • GTPase activity |
| • Signal transduction | • Intracellular signal transduction |
Pathways
• RAS signaling pathway
• MAPK signaling pathway
Protein Summary
The RASL11A protein is a small GTPase of the RAS superfamily, predicted to cycle between active GTP-bound and inactive GDP-bound states. It may modulate cell proliferation and differentiation through interaction with downstream effectors. Structural analysis indicates a conserved G-domain typical of RAS proteins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RASL11A Knockout HEK293 Cell Line | EDJ-KQ14995 | Human | 387496 | Details Get a Quote |
| RASL11A Knockout A-549 Cell Line | EDJ-KQ45510 | Human | 387496 | Details Get a Quote |
| RASL11A Knockout HCT 116 Cell Line | EDJ-KQ45511 | Human | 387496 | Details Get a Quote |
| RASL11A Knockout HeLa Cell Line | EDJ-KQ59976 | Human | 387496 | Details Get a Quote |
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