RASL10B
RAS Like Family 10 Member B
Gene Information Card
| Symbol | RASL10B |
|---|---|
| Full Name | RAS Like Family 10 Member B |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 91608 ncbi.nlm.nih.gov/gene/91608 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q9NZN5 |
| OMIM ID | 612949 |
| HGNC ID | 30248 |
| Aliases | RASL10B, RP11-54O7.1 |
Description
RASL10B (RAS Like Family 10 Member B) is a protein-coding gene belonging to the RAS superfamily of small GTPases. It is involved in signal transduction pathways regulating cell proliferation, differentiation, and apoptosis. The gene is located on chromosome 17q21.2 and encodes a 198-amino acid protein. RASL10B is also known as a putative tumor suppressor, with evidence of downregulation in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Downregulation or loss of RASL10B expression may contribute to tumorigenesis by disrupting RAS signaling pathways. | COSMIC; literature review |
| No specific Mendelian disease reported | Not applicable | OMIM; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Moderate expression |
| HeLa | 10.2 | Moderate expression |
| A549 | 7.8 | Low expression |
| MCF7 | 5.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Unknown functional impact |
| c.205C>T (p.Arg69Trp) | Missense | <0.01% | Unknown functional impact |
| c.358_359insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.358_359insA) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding | • GTPase activity |
| • signal transduction | • intracellular signal transduction |
| • regulation of cell proliferation | • negative regulation of cell growth |
Pathways
• RAS signaling pathway
• MAPK signaling pathway
• Regulation of actin cytoskeleton
Protein Summary
RASL10B encodes a small GTPase of the RAS superfamily. The protein binds GTP and exhibits intrinsic GTPase activity, cycling between active GTP-bound and inactive GDP-bound states. It functions as a molecular switch in signaling cascades that control cell growth and differentiation. Structural analysis reveals a conserved G domain with key motifs for nucleotide binding and hydrolysis. RASL10B is implicated in tumor suppression, with reduced expression observed in several cancer types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RASL10B Knockout HEK293 Cell Line | EDJ-KQ10752 | Human | 91608 | Details Get a Quote |
| RASL10B Knockout HeLa Cell Line | EDJ-KQ38344 | Human | 91608 | Details Get a Quote |
| RASL10B Knockout A-549 Cell Line | EDJ-KQ66302 | Human | 91608 | Details Get a Quote |
| RASL10B Knockout HCT 116 Cell Line | EDJ-KQ74725 | Human | 91608 | Details Get a Quote |
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