RASL10A
RAS Like Family 10 Member A
Gene Information Card
| Symbol | RASL10A |
|---|---|
| Full Name | RAS Like Family 10 Member A |
| Gene Type | protein-coding |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 10633 ncbi.nlm.nih.gov/gene/10633 |
| Ensembl ID | ENSG00000100368 |
| UniProt ID | Q9H0H5 |
| OMIM ID | 612949 |
| HGNC ID | 30258 |
| Aliases | RASL10, RRP22 |
Description
RASL10A (RAS Like Family 10 Member A) is a protein-coding gene located on chromosome 22q12.2. It encodes a member of the RAS superfamily of small GTPases, which function as molecular switches in signal transduction pathways. RASL10A is thought to play a role in cell growth, differentiation, and apoptosis. The gene is also known as RRP22 (Ras-related protein 22).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered expression of RASL10A may affect neuronal signaling pathways; genetic association studies have linked variants to schizophrenia risk. | PMID: 21362589 |
| Lung Cancer | RASL10A is hypermethylated and silenced in non-small cell lung cancer, suggesting a tumor suppressor role. | PMID: 20068070 |
| Glioma | Reduced expression of RASL10A in glioblastoma correlates with poor prognosis; may regulate cell proliferation. | PMID: 22037527 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 3.2 | Low |
| Lung | 1.8 | Low |
| Testis | 4.5 | Medium |
| Heart | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.1 | Low expression |
| A549 | 1.3 | Low expression |
| U87MG | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.47G>A (p.Arg16His) | Missense | <0.1% | Unknown functional impact |
| c.112C>T (p.Arg38Trp) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Hypermethylation and silencing of RASL10A in lung cancer and glioma suggest loss-of-function as a tumor suppressor.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding | • GTPase activity |
| • signal transduction | • regulation of cell proliferation |
| • apoptotic process |
Pathways
• RAS signaling pathway
• MAPK signaling pathway
Protein Summary
RASL10A encodes a 198-amino acid protein (UniProt Q9H0H5) belonging to the RAS superfamily of small GTPases. It contains conserved GTP-binding and hydrolysis domains. The protein is localized to the plasma membrane and is involved in signal transduction, regulating cell growth and apoptosis. RASL10A is frequently silenced by promoter hypermethylation in several cancers, indicating a potential tumor suppressor function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RASL10A Knockout HEK293 Cell Line | EDJ-KQ7112 | Human | 10633 | Details Get a Quote |
| RASL10A Knockout HeLa Cell Line | EDJ-KQ55449 | Human | 10633 | Details Get a Quote |
| RASL10A Knockout A-549 Cell Line | EDJ-KQ63931 | Human | 10633 | Details Get a Quote |
| RASL10A Knockout HCT 116 Cell Line | EDJ-KQ72388 | Human | 10633 | Details Get a Quote |
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