RALA Gene - RALA Ras Like Proto-Oncogene A
Comprehensive biomedical resource for RALA: function, expression, mutations, and disease associations.
Gene Information Card
| Symbol | RALA |
|---|---|
| Full Name | ras like proto-oncogene A |
| Gene Type | protein coding |
| Chromosomal Location | 7p15.2 |
| NCBI Gene ID | 5898 ncbi.nlm.nih.gov/gene/5898 |
| Ensembl ID | ENSG00000106462 |
| UniProt ID | P11233 |
| OMIM ID | 179550 |
| HGNC ID | 9839 |
| Aliases | RALA, RALA1, RALA2, RALA3, RALA4, RALA5, RALA6, RALA7, RALA8, RALA9, RALA10 |
Description
RALA (ras like proto-oncogene A) is a protein-coding gene that encodes a small GTPase belonging to the Ras superfamily. RALA functions as a molecular switch in signal transduction pathways regulating cell proliferation, differentiation, cytoskeletal organization, and vesicle trafficking. It is implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | RALA gain-of-function mutations and overexpression promote oncogenic signaling via RALGEF-RAL pathway activation. | COSMIC, ClinVar, literature |
| Intellectual disability | De novo missense variants in RALA have been associated with neurodevelopmental disorders. | ClinVar, literature |
| Noonan syndrome-like disorder | Rare RALA variants may contribute to RASopathy phenotypes. | OMIM, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
| Thyroid | 11.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| A549 | 10.2 | Lung cancer cell line |
| MCF7 | 8.9 | Breast cancer cell line |
| HEK293 | 12.1 | Embryonic kidney cell line |
| K562 | 7.3 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.47G>A (p.Gly16Asp) | Missense | <0.1% | Gain-of-function; increased GTP binding |
| c.109C>T (p.Arg37Cys) | Missense | <0.1% | Unknown; reported in neurodevelopmental disorders |
| c.113A>G (p.Glu38Gly) | Missense | <0.1% | Gain-of-function; enhanced RALGEF interaction |
| c.205G>A (p.Glu69Lys) | Missense | <0.1% | Loss-of-function; impaired GTPase activity |
Mutation functional classification
Loss of Function (LOF)
Mutations impairing GTP hydrolysis or effector binding, e.g., p.Glu69Lys.
Gain of Function (GOF)
Mutations increasing GTP-bound active state, e.g., p.Gly16Asp, p.Glu38Gly.
Dominant Negative (DN)
Not well characterized for RALA; some mutants may sequester effectors.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activity | • GTP binding |
| • protein binding | • small GTPase mediated signal transduction |
| • Ras protein signal transduction | • cell proliferation |
| • cytoskeleton organization | • vesicle-mediated transport |
Pathways
• Ral signaling pathway
• Ras signaling pathway
• RalA downstream signaling
• Regulation of exocytosis
• Cell migration
Protein Summary
RALA is a 206-amino acid small GTPase (UniProt P11233) that cycles between an inactive GDP-bound and active GTP-bound state. It is anchored to the plasma membrane via C-terminal prenylation. RALA regulates exocytosis, filopodia formation, and cell motility. It is frequently overexpressed or mutated in cancers, particularly in bladder, pancreatic, and colorectal tumors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RALA Knockout HEK293 Cell Line | EDJ-KQ1248 | Human | 5898 | Details Get a Quote |
| RALA Knockout A-549 Cell Line | EDJ-KQ20617 | Human | 5898 | Details Get a Quote |
| RALA Knockout HCT 116 Cell Line | EDJ-KQ20618 | Human | 5898 | Details Get a Quote |
| RALA Knockout HeLa Cell Line | EDJ-KQ20619 | Human | 5898 | Details Get a Quote |
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