PTPN3
Protein Tyrosine Phosphatase Non-Receptor Type 3
Gene Information Card
| Symbol | PTPN3 |
|---|---|
| Full Name | Protein Tyrosine Phosphatase Non-Receptor Type 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q31.3 |
| NCBI Gene ID | 5774 ncbi.nlm.nih.gov/gene/5774 |
| Ensembl ID | ENSG00000170160 |
| UniProt ID | P26045 |
| OMIM ID | 176877 |
| HGNC ID | 9655 |
| Aliases | PTPH1, PTPN3, protein tyrosine phosphatase, non-receptor type 3 |
Description
PTPN3 encodes a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal catalytic domain and an N-terminal domain with homology to the band 4.1 superfamily, which may localize the protein to the cytoskeleton. Alternative splicing results in multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Loss of PTPN3 expression may promote tumorigenesis through altered MAPK signaling | PMID: 22198284 |
| Hepatocellular carcinoma | PTPN3 mutations may affect JNK signaling and cell proliferation | PMID: 24803677 |
| Breast cancer | Reduced PTPN3 expression correlates with poor prognosis | PMID: 25485619 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.7 | Medium |
| Kidney | 10.2 | Medium |
| Lung | 6.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.5 | Embryonic kidney |
| HeLa | 9.2 | Cervical cancer |
| HepG2 | 18.1 | Hepatocellular carcinoma |
| MCF7 | 7.4 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function |
| c.890A>G (p.Tyr297Cys) | Missense | 0.2% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons and truncated protein.
Gain of Function (GOF)
Not reported in COSMIC or ClinVar.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • dephosphorylation |
| • signal transduction | • cytoskeleton organization |
Pathways
• MAPK signaling pathway
• JNK cascade
• ErbB signaling pathway
Protein Summary
PTPN3 is a 913-amino acid protein with a molecular weight of approximately 104 kDa. It contains an N-terminal FERM domain (band 4.1, ezrin, radixin, moesin) and a C-terminal protein tyrosine phosphatase catalytic domain. The FERM domain mediates interaction with the cytoskeleton, while the phosphatase domain dephosphorylates tyrosine residues on target proteins, modulating signaling pathways such as MAPK and JNK.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTPN3 Knockout HEK293 Cell Line | EDJ-KQ5592 | Human | 5774 | Details Get a Quote |
| PTPN3 Knockout A-549 Cell Line | EDJ-KQ27611 | Human | 5774 | Details Get a Quote |
| PTPN3 Knockout HCT 116 Cell Line | EDJ-KQ28860 | Human | 5774 | Details Get a Quote |
| PTPN3 Knockout HeLa Cell Line | EDJ-KQ28861 | Human | 5774 | Details Get a Quote |
