PTGFR (Prostaglandin F Receptor)
FP receptor, a G-protein coupled receptor for prostaglandin F2α, involved in smooth muscle contraction, parturition, and glaucoma pathogenesis.
Gene Information Card
| Symbol | PTGFR |
|---|---|
| Full Name | Prostaglandin F Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 1p31.1 |
| NCBI Gene ID | 5737 ncbi.nlm.nih.gov/gene/5737 |
| Ensembl ID | ENSG00000122420 |
| UniProt ID | P43088 |
| OMIM ID | 600563 |
| HGNC ID | 9599 |
| Aliases | FP, FP receptor, PTGFR1 |
Description
The PTGFR gene encodes the prostaglandin F receptor (FP), a member of the G-protein coupled receptor family. This receptor binds prostaglandin F2α (PGF2α) and mediates its physiological effects, including smooth muscle contraction, luteolysis, and induction of labor. It is also a therapeutic target in glaucoma, where FP receptor agonists reduce intraocular pressure.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glaucoma (primary open-angle) | FP receptor activation lowers intraocular pressure; mutations may alter receptor function | ClinVar, OMIM |
| Preterm labor | PGF2α signaling via FP receptor induces uterine contractions; dysregulation linked to preterm birth | OMIM, PubMed |
| Corpus luteum regression (luteolysis) | FP receptor mediates luteolysis; aberrant signaling may affect fertility | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Uterus | 12.3 | Medium |
| Eye (ciliary body) | 8.7 | Medium |
| Ovary | 6.5 | Low |
| Lung | 4.2 | Low |
| Kidney | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Overexpressed in recombinant systems |
| HeLa | 2.1 | Endogenous expression |
| A549 | 1.8 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.125G>A (p.Arg42His) | missense | <0.01% | Unknown; predicted benign |
| c.682C>T (p.Arg228Cys) | missense | <0.01% | Unknown; predicted possibly damaging |
| c.1037_1038insA | frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions or nonsense variants that truncate the receptor, impairing PGF2α binding and signaling.
Gain of Function (GOF)
Not well documented; activating mutations are rare and not clinically characterized.
Dominant Negative (DN)
No dominant-negative variants reported in PTGFR.
View complete mutation data：
Gene Ontology (GO)
| • G-protein coupled receptor activity | • prostaglandin F receptor activity |
| • plasma membrane | • signal transduction |
| • smooth muscle contraction | • luteolysis |
| • positive regulation of cytosolic calcium ion concentration |
Pathways
• Prostanoid signaling pathway
• GPCR downstream signaling
• Smooth muscle contraction
Protein Summary
The PTGFR protein (FP receptor) is a 359-amino acid G-protein coupled receptor with seven transmembrane domains. Upon binding PGF2α, it activates Gq/11 proteins, leading to phospholipase C activation, inositol trisphosphate production, and intracellular calcium mobilization. This triggers smooth muscle contraction, luteolysis, and regulation of intraocular pressure.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGFR Knockout HEK293 Cell Line | EDJ-KQ1600 | Human | 5737 | Details Get a Quote |
| PTGFRN Knockout HEK293 Cell Line | EDJ-KQ3249 | Human | 5738 | Details Get a Quote |
| PTGFRN Knockout A-549 Cell Line | EDJ-KQ23391 | Human | 5738 | Details Get a Quote |
| PTGFRN Knockout HCT 116 Cell Line | EDJ-KQ24783 | Human | 5738 | Details Get a Quote |
| PTGFRN Knockout HeLa Cell Line | EDJ-KQ24784 | Human | 5738 | Details Get a Quote |
| PTGFR Knockout HeLa Cell Line | EDJ-KQ54259 | Human | 5737 | Details Get a Quote |
| PTGFR Knockout A-549 Cell Line | EDJ-KQ62750 | Human | 5737 | Details Get a Quote |
| PTGFR Knockout HCT 116 Cell Line | EDJ-KQ71218 | Human | 5737 | Details Get a Quote |
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