PTGER1: Prostaglandin E Receptor 1
GPCR for PGE2 signaling in pain, inflammation, and reproduction
Gene Information Card
| Symbol | PTGER1 |
|---|---|
| Full Name | Prostaglandin E Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.12 |
| NCBI Gene ID | 5731 ncbi.nlm.nih.gov/gene/5731 |
| Ensembl ID | ENSG00000160991 |
| UniProt ID | P34995 |
| OMIM ID | 176802 |
| HGNC ID | 9593 |
| Aliases | EP1, EP1R, PGE2 receptor EP1 subtype |
Description
PTGER1 encodes the prostaglandin E receptor 1 (EP1), a G protein-coupled receptor (GPCR) that binds prostaglandin E2 (PGE2). Activation of EP1 leads to increased intracellular calcium via Gq/11-mediated phospholipase C signaling. PTGER1 is involved in pain perception, inflammation, blood pressure regulation, and reproductive functions. It is expressed in various tissues including kidney, lung, stomach, and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | EP1 activation in renal vasculature promotes vasoconstriction and sodium retention | OMIM 176802; PMID 10716718 |
| Inflammatory pain | PGE2-EP1 signaling sensitizes nociceptors in peripheral tissues | PMID 12604797 |
| Gastric ulcer | EP1 mediates PGE2-induced gastric mucosal protection; antagonism increases ulcer risk | PMID 11498510 |
| Colorectal cancer | EP1 overexpression promotes tumor cell proliferation and invasion | COSMIC; PMID 19165146 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Lung | 8.3 | Low |
| Stomach | 15.1 | Medium |
| Brain | 6.7 | Low |
| Uterus | 18.9 | Medium |
| Testis | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 22.0 | Overexpressed in recombinant systems |
| A549 (lung cancer) | 9.8 | Endogenous expression |
| HCT116 (colorectal cancer) | 14.3 | Endogenous expression |
| MCF7 (breast cancer) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.01% | Reduced ligand binding affinity (ClinVar) |
| c.341C>T (p.Pro114Leu) | Missense | <0.01% | Altered G protein coupling (ClinVar) |
| c.682G>A (p.Gly228Arg) | Missense | <0.01% | Loss of function (COSMIC) |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Gly228Arg) impair receptor activation or ligand binding, reducing PGE2 signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PTGER1.
Dominant Negative (DN)
No dominant-negative mutations described for PTGER1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Prostanoid signaling (Reactome R-HSA-416476)
• GPCR downstream signaling (Reactome R-HSA-388396)
• PGE2-EP1 pathway in pain (KEGG hsa04726)
Protein Summary
PTGER1 (EP1) is a 402-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by prostaglandin E2 and couples primarily to Gq/11, leading to phospholipase C activation, inositol trisphosphate production, and intracellular calcium mobilization. EP1 is expressed in kidney, stomach, lung, and reproductive tissues, and plays roles in pain, inflammation, blood pressure regulation, and gastric mucosal protection. Mutations are rare but can affect receptor function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGER1 Knockout HEK293 Cell Line | EDJ-KQ1598 | Human | 5731 | Details Get a Quote |
| PTGER1 Knockout HeLa Cell Line | EDJ-KQ54256 | Human | 5731 | Details Get a Quote |
| PTGER1 Knockout A-549 Cell Line | EDJ-KQ62747 | Human | 5731 | Details Get a Quote |
| PTGER1 Knockout HCT 116 Cell Line | EDJ-KQ71216 | Human | 5731 | Details Get a Quote |
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