PRMT6 (Protein Arginine Methyltransferase 6)
A type I arginine methyltransferase involved in transcriptional regulation, RNA processing, and DNA repair, with implications in cancer and viral infections.
Gene Information Card
| Symbol | PRMT6 |
|---|---|
| Full Name | Protein Arginine Methyltransferase 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p13.3 |
| NCBI Gene ID | 55170 ncbi.nlm.nih.gov/gene/55170 |
| Ensembl ID | ENSG00000198890 |
| UniProt ID | Q96LA8 |
| OMIM ID | 608274 |
| HGNC ID | 18221 |
| Aliases | HRMT1L6, HMT1, HMT1 hnRNP methyltransferase-like 6 |
Description
PRMT6 encodes a type I protein arginine methyltransferase that catalyzes the formation of asymmetric dimethylarginine (ADMA) on histone and non-histone proteins. It is involved in transcriptional repression, RNA processing, DNA damage response, and viral replication. PRMT6 is overexpressed in several cancers and has been implicated in tumorigenesis and poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PRMT6 overexpression promotes cell proliferation and migration via methylation of histone H3R2 and non-histone targets such as NF-κB. | PMID: 25977310 |
| Prostate cancer | PRMT6 enhances androgen receptor signaling and tumor growth through arginine methylation of histone H4R3. | PMID: 31073040 |
| HIV-1 infection | PRMT6 methylates HIV-1 Tat protein, reducing its transactivation activity and inhibiting viral replication. | PMID: 16912299 |
| Lung cancer | PRMT6 upregulation correlates with poor survival and promotes epithelial-mesenchymal transition (EMT). | PMID: 31570863 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 9.8 | Medium |
| Bone marrow | 8.2 | Low |
| Brain | 4.1 | Low |
| Liver | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 11.0 | Moderate expression |
| MCF7 | 9.5 | Moderate expression |
| A549 | 7.8 | Low expression |
| K562 | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437G>A (p.Arg146Gln) | Missense | <0.01% | Unknown functional impact |
| c.682C>T (p.Arg228Trp) | Missense | <0.01% | Unknown functional impact |
| c.1015_1016insA (p.Thr339Asnfs*2) | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr339Asnfs*2) likely result in truncated, non-functional protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PRMT6.
Dominant Negative (DN)
No evidence of dominant-negative effects for PRMT6 mutations.
View complete mutation data：
Gene Ontology (GO)
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
| • methyltransferase activity (GO:0008168) | • protein-arginine N-methyltransferase activity (GO:0016274) |
| • asymmetric dimethylarginine formation (GO:0035241) | • regulation of transcription (GO:0006355) |
| • cellular response to DNA damage stimulus (GO:0006974) |
Pathways
• Arginine and proline metabolism
• Transcriptional misregulation in cancer
• p53 signaling pathway (via methylation of p53)
Protein Summary
PRMT6 is a 375-amino acid protein (42 kDa) that belongs to the protein arginine methyltransferase family. It contains a conserved methyltransferase domain and specifically generates asymmetric dimethylarginine residues. PRMT6 methylates histone H3 at arginine 2 (H3R2me2a), leading to transcriptional repression, and also modifies non-histone proteins such as p53, NF-κB, and HIV-1 Tat. Its activity is implicated in cell cycle regulation, DNA repair, and viral restriction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRMT6 Knockout HEK293 Cell Line | EDJ-KQ2490 | Human | 55170 | Details Get a Quote |
| PRMT6 Knockout HCT 116 Cell Line | EDJ-KQ23079 | Human | 55170 | Details Get a Quote |
| PRMT6 Knockout HeLa Cell Line | EDJ-KQ23080 | Human | 55170 | Details Get a Quote |
| PRMT6 Knockout A-549 Cell Line | EDJ-KQ65042 | Human | 55170 | Details Get a Quote |
