PRLHR
Prolactin Releasing Hormone Receptor
Gene Information Card
| Symbol | PRLHR |
|---|---|
| Full Name | Prolactin Releasing Hormone Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 10q11.22 |
| NCBI Gene ID | 2834 ncbi.nlm.nih.gov/gene/2834 |
| Ensembl ID | ENSG00000119973 |
| UniProt ID | P49683 |
| OMIM ID | 600895 |
| HGNC ID | 9363 |
| Aliases | GPR10, GrPR, hGR3 |
Description
PRLHR encodes the prolactin-releasing hormone receptor, a G-protein coupled receptor (GPCR) that binds prolactin-releasing peptide (PrRP). It is primarily expressed in the pituitary, brain, and peripheral tissues, and plays a role in neuroendocrine regulation, including prolactin secretion, stress response, energy homeostasis, and pain modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | PRLHR signaling modulates energy balance and appetite; loss-of-function variants are associated with increased body weight in animal models. | NCBI Gene, OMIM |
| Prolactinoma | PRLHR expression is altered in pituitary adenomas, potentially affecting prolactin secretion. | NCBI Gene, COSMIC |
| Breast Cancer | PRLHR is overexpressed in some breast cancer cell lines and may influence tumor growth via GPCR signaling. | COSMIC, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pituitary | 12.5 | Medium |
| Hypothalamus | 8.3 | Low |
| Adrenal Gland | 6.1 | Low |
| Placenta | 4.7 | Low |
| Breast | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 5.1 | Moderate expression |
| HEK293 (embryonic kidney) | 2.3 | Low expression |
| SH-SY5Y (neuroblastoma) | 4.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67Gln) | Missense | <0.01% | Unknown functional effect |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Potential loss of function |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense and start-loss variants (e.g., p.Met1Val) likely impair receptor expression or signaling.
Gain of Function (GOF)
No gain-of-function mutations reported in PRLHR.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuropeptide receptor activity |
| • prolactin-releasing peptide receptor activity | • plasma membrane |
| • signal transduction | • adenylate cyclase-activating G protein-coupled receptor signaling pathway |
Pathways
• GPCR downstream signaling
• Neuropeptide signaling pathway
• Prolactin regulation
Protein Summary
PRLHR is a 377-amino acid GPCR with seven transmembrane domains. It is activated by PrRP, leading to intracellular calcium mobilization and inhibition of cAMP production. The receptor is involved in neuroendocrine functions, including prolactin release, stress response, and energy homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRLHR Knockout HEK293 Cell Line | EDJ-KQ4777 | Human | 2834 | Details Get a Quote |
| PRLHR Knockout HeLa Cell Line | EDJ-KQ53389 | Human | 2834 | Details Get a Quote |
| PRLHR Knockout A-549 Cell Line | EDJ-KQ61867 | Human | 2834 | Details Get a Quote |
| PRLHR Knockout HCT 116 Cell Line | EDJ-KQ70349 | Human | 2834 | Details Get a Quote |
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