PRELID3A Gene
PRELI Domain Containing 3A
Gene Information Card
| Symbol | PRELID3A |
|---|---|
| Full Name | PRELI domain containing 3A |
| Gene Type | Protein coding |
| Chromosomal Location | 18q12.1 |
| NCBI Gene ID | 653319 ncbi.nlm.nih.gov/gene/653319 |
| Ensembl ID | ENSG00000187792 |
| UniProt ID | Q5T4S7 |
| OMIM ID | 618440 |
| HGNC ID | 33785 |
| Aliases | C18orf26, FLJ39653, UBX10 |
Description
PRELID3A (PRELI domain containing 3A) is a protein-coding gene located on chromosome 18q12.1. It encodes a protein containing a PRELI (protein of relevant evolutionary and lymphoid interest) domain, which is involved in lipid transport and mitochondrial function. The gene is also known as UBX10 due to its UBX domain. PRELID3A is conserved across species and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.0 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • molecular_function (GO:0003674) | • cellular_component (GO:0005575) |
| • biological_process (GO:0008150) |
Protein Summary
The PRELID3A protein contains a PRELI domain and a UBX domain. It is predicted to be involved in lipid transport and may play a role in mitochondrial function. The UBX domain suggests interaction with ubiquitin-related processes. Further functional characterization is needed.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRELID3A Knockout HEK293 Cell Line | EDJ-KQ7117 | Human | 10650 | Details Get a Quote |
| PRELID3A Knockout A-549 Cell Line | EDJ-KQ31989 | Human | 10650 | Details Get a Quote |
| PRELID3A Knockout HCT 116 Cell Line | EDJ-KQ31990 | Human | 10650 | Details Get a Quote |
| PRELID3A Knockout HeLa Cell Line | EDJ-KQ30611 | Human | 10650 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
