PRELID2
PRELI domain containing 2
Gene Information Card
| Symbol | PRELID2 |
|---|---|
| Full Name | PRELI domain containing 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 153768 ncbi.nlm.nih.gov/gene/153768 |
| Ensembl ID | ENSG00000185043 |
| UniProt ID | Q8N945 |
| OMIM ID | 617119 |
| HGNC ID | 28325 |
| Aliases | FLJ22662, MGC13170 |
Description
PRELID2 (PRELI domain containing 2) is a protein-coding gene located on chromosome 5q35.3. It encodes a protein containing a PRELI domain, which is involved in phospholipid transport and mitochondrial function. The gene is expressed in various tissues and may play a role in cellular lipid homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Spleen | 7.1 | Low |
| Bone marrow | 6.8 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Moderate expression |
| HeLa | 10.2 | Low expression |
| K562 | 8.5 | Low expression |
| HepG2 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • phospholipid transport | • mitochondrion |
| • PRELI domain |
Pathways
• No specific pathway annotations in Reactome or KEGG
Protein Summary
The PRELID2 protein contains a PRELI domain, which is characteristic of proteins involved in phospholipid transfer between membranes, particularly in mitochondria. Its exact molecular function remains under investigation, but it is predicted to contribute to lipid homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRELID2 Knockout HEK293 Cell Line | EDJ-KQ11537 | Human | 153768 | Details Get a Quote |
| PRELID2 Knockout A-549 Cell Line | EDJ-KQ39858 | Human | 153768 | Details Get a Quote |
| PRELID2 Knockout HCT 116 Cell Line | EDJ-KQ39859 | Human | 153768 | Details Get a Quote |
| PRELID2 Knockout HeLa Cell Line | EDJ-KQ39860 | Human | 153768 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
