PRDX3: Peroxiredoxin 3 – Mitochondrial Antioxidant and Redox Regulator
A comprehensive biomedical SEO guide to PRDX3 gene, including genomic annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | PRDX3 |
|---|---|
| Full Name | Peroxiredoxin 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q26.11 |
| NCBI Gene ID | 10935 ncbi.nlm.nih.gov/gene/10935 |
| Ensembl ID | ENSG00000165672 |
| UniProt ID | P30048 |
| OMIM ID | 604769 |
| HGNC ID | 9354 |
| Aliases | AOP-1, MER5, SP-22, PRX3, HBC189 |
Description
PRDX3 encodes peroxiredoxin 3, a mitochondrial member of the peroxiredoxin family of antioxidant enzymes. It reduces hydrogen peroxide and alkyl hydroperoxides, protecting mitochondria from oxidative damage. PRDX3 is involved in redox signaling, cell proliferation, and apoptosis regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PRDX3 overexpression promotes tumor growth by reducing oxidative stress and enhancing cell survival. | PMID: 21502527; COSMIC |
| Lung cancer | Increased PRDX3 expression correlates with poor prognosis; protects cancer cells from chemotherapy-induced ROS. | PMID: 23327987; COSMIC |
| Neurodegenerative disorders (e.g., Alzheimer's disease) | PRDX3 dysfunction leads to mitochondrial oxidative stress and neuronal cell death. | PMID: 22956769; ClinVar |
| Hepatocellular carcinoma | PRDX3 upregulation supports proliferation and metastasis via ROS scavenging. | PMID: 25655998; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Heart | 10.8 | Medium |
| Kidney | 9.2 | Medium |
| Brain | 7.1 | Low |
| Skeletal muscle | 6.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.3 | Hepatocellular carcinoma cell line |
| A549 | 11.7 | Lung adenocarcinoma cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| SH-SY5Y | 6.2 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.568G>A (p.Gly190Arg) | Missense | <0.01% | Unknown functional effect; reported in ClinVar |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Predicted loss of function; ClinVar |
| c.364C>T (p.Arg122Trp) | Missense | <0.01% | May affect protein stability; COSMIC |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) likely abolish translation, reducing antioxidant capacity.
Gain of Function (GOF)
Not well documented; overexpression in cancers suggests possible gain-of-function via increased ROS scavenging.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Detoxification of Reactive Oxygen Species (Reactome: R-HSA-3299685)
• Peroxiredoxin-mediated reduction of H2O2 (Reactome: R-HSA-6787403)
• Oxidative Stress Response (KEGG: hsa04066)
Protein Summary
PRDX3 is a 256-amino-acid mitochondrial peroxiredoxin that reduces hydrogen peroxide and organic hydroperoxides using thioredoxin as an electron donor. It forms homodimers and undergoes redox-sensitive oligomerization. PRDX3 protects cells from oxidative stress, modulates apoptosis, and is implicated in cancer progression and neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDX3 Knockout HEK293 Cell Line | EDJ-KQ7218 | Human | 10935 | Details Get a Quote |
| PRDX3 Knockout A-549 Cell Line | EDJ-KQ32173 | Human | 10935 | Details Get a Quote |
| PRDX3 Knockout HCT 116 Cell Line | EDJ-KQ32174 | Human | 10935 | Details Get a Quote |
| PRDX3 Knockout HeLa Cell Line | EDJ-KQ32175 | Human | 10935 | Details Get a Quote |
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