PRDM15
PR/SET Domain 15 – Transcriptional Regulator in Development and Disease
Gene Information Card
| Symbol | PRDM15 |
|---|---|
| Full Name | PR/SET Domain 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 21q22.3 |
| NCBI Gene ID | 63977 ncbi.nlm.nih.gov/gene/63977 |
| Ensembl ID | ENSG00000141956 |
| UniProt ID | Q9H8H2 |
| OMIM ID | 617527 |
| HGNC ID | 13999 |
| Aliases | ZNF298, PFM9 |
Description
PRDM15 (PR/SET domain 15) encodes a zinc finger transcription factor that belongs to the PRDM family. It contains an N-terminal PR domain (related to SET methyltransferase domains) and multiple C2H2 zinc finger motifs. PRDM15 is involved in transcriptional regulation, cell proliferation, and differentiation. It plays a role in embryonic development and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hodgkin lymphoma | PRDM15 overexpression may contribute to tumorigenesis by regulating cell cycle genes. | PMID: 25670082 |
| Colorectal cancer | PRDM15 promotes Wnt/β-catenin signaling, enhancing proliferation. | PMID: 28712719 |
| Breast cancer | PRDM15 expression correlates with poor prognosis and metastasis. | PMID: 31073040 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Lymph node | 8.7 | Medium |
| Bone marrow | 6.5 | Low |
| Brain | 3.2 | Low |
| Liver | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.4 | High expression |
| HeLa | 10.2 | Moderate expression |
| MCF7 | 7.8 | Low expression |
| K562 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123C>T (p.Arg375Trp) | Missense | <0.01% | Unknown functional effect |
| c.1456G>A (p.Gly486Ser) | Missense | <0.01% | Unknown functional effect |
| c.1789_1790insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1789_1790insA) are predicted to cause premature truncation and loss of DNA-binding or PR domain function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PRDM15.
Dominant Negative (DN)
No evidence for dominant-negative effects in PRDM15.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway
• Transcriptional regulation by PRDM family
Protein Summary
PRDM15 is a 1,210-amino acid nuclear protein containing a PR domain and 12 C2H2 zinc fingers. It functions as a sequence-specific DNA-binding transcription factor that can both activate and repress target genes. PRDM15 is involved in regulating cell cycle progression, differentiation, and Wnt/β-catenin signaling. Its expression is enriched in testis and lymphoid tissues, and dysregulation is associated with several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDM15 Knockout HEK293 Cell Line | EDJ-KQ12218 | Human | 63977 | Details Get a Quote |
| PRDM15 Knockout A-549 Cell Line | EDJ-KQ40963 | Human | 63977 | Details Get a Quote |
| PRDM15 Knockout HCT 116 Cell Line | EDJ-KQ40964 | Human | 63977 | Details Get a Quote |
| PRDM15 Knockout HeLa Cell Line | EDJ-KQ40965 | Human | 63977 | Details Get a Quote |
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