PRDM10 Gene: PR/SET Domain 10
Transcriptional regulator involved in development and cancer
Gene Information Card
| Symbol | PRDM10 |
|---|---|
| Full Name | PR/SET Domain 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q24.3 |
| NCBI Gene ID | 56980 ncbi.nlm.nih.gov/gene/56980 |
| Ensembl ID | ENSG00000110395 |
| UniProt ID | Q9NQV6 |
| OMIM ID | 618174 |
| HGNC ID | 13987 |
| Aliases | FLJ10718, MGC138290, PR-domain zinc finger protein 10 |
Description
PRDM10 (PR/SET Domain 10) is a protein-coding gene that encodes a transcriptional regulator belonging to the PRDM family. The protein contains an N-terminal PR domain (a subtype of SET domain) and multiple C-terminal zinc finger motifs, suggesting a role in chromatin remodeling and gene expression regulation. PRDM10 is involved in developmental processes and has been implicated in oncogenesis, particularly through recurrent gene fusions in soft tissue sarcomas.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Soft tissue sarcoma (myxoinflammatory fibroblastic sarcoma, hemosiderotic fibrolipomatous tumor) | Recurrent PRDM10 gene fusions (e.g., PRDM10-MGEA5, PRDM10-CITED2) result in chimeric proteins that likely alter transcriptional regulation and promote tumorigenesis. | PMID: 25670082, 30352677 |
| Undifferentiated pleomorphic sarcoma | PRDM10 rearrangements identified in a subset of cases, suggesting a driver role. | PMID: 30352677 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 5.1 | Low |
| Heart | 3.8 | Low |
| Liver | 1.2 | Not detected |
| Kidney | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.7 | Embryonic kidney cells |
| HeLa | 6.4 | Cervical carcinoma cells |
| K562 | 4.2 | Leukemia cells |
| MCF7 | 3.1 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| PRDM10-MGEA5 fusion | Gene fusion | Recurrent in myxoinflammatory fibroblastic sarcoma | Chimeric protein with altered function |
| PRDM10-CITED2 fusion | Gene fusion | Recurrent in hemosiderotic fibrolipomatous tumor | Chimeric protein with altered function |
| Missense variants (e.g., p.Arg425Trp) | Missense | Rare | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; no clear loss-of-function mutations reported.
Gain of Function (GOF)
PRDM10 fusions are thought to act as gain-of-function oncoproteins by aberrantly activating target genes.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not assigned to any specific KEGG or Reactome pathway.
Protein Summary
PRDM10 is a 1,084-amino acid protein containing an N-terminal PR domain (similar to SET methyltransferases) and six C2H2-type zinc fingers. It localizes to the nucleus and likely functions as a sequence-specific transcription factor involved in chromatin regulation. The protein is expressed in multiple tissues, with highest levels in testis. Recurrent gene fusions involving PRDM10 are oncogenic drivers in soft tissue sarcomas.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDM10 Knockout HEK293 Cell Line | EDJ-KQ14888 | Human | 56980 | Details Get a Quote |
| PRDM10 Knockout HCT 116 Cell Line | EDJ-KQ45331 | Human | 56980 | Details Get a Quote |
| PRDM10 Knockout HeLa Cell Line | EDJ-KQ45332 | Human | 56980 | Details Get a Quote |
| PRDM10 Knockout A-549 Cell Line | EDJ-KQ65287 | Human | 56980 | Details Get a Quote |
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