PRCP (Prolylcarboxypeptidase) Gene
Functional and Clinical Insights into PRCP
Gene Information Card
| Symbol | PRCP |
|---|---|
| Full Name | Prolylcarboxypeptidase |
| Gene Type | Protein coding |
| Chromosomal Location | 11q14.1 |
| NCBI Gene ID | 5547 ncbi.nlm.nih.gov/gene/5547 |
| Ensembl ID | ENSG00000137575 |
| UniProt ID | P42785 |
| OMIM ID | 176785 |
| HGNC ID | 9344 |
| Aliases | PCP, HUMPCP, lysosomal carboxypeptidase, angiotensinase C |
Description
PRCP encodes prolylcarboxypeptidase, a lysosomal serine carboxypeptidase that cleaves C-terminal amino acids linked to proline. It is involved in the renin-angiotensin system, inactivating angiotensin II and III, and plays roles in blood pressure regulation, inflammation, and energy metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | PRCP deficiency reduces angiotensin II degradation, potentially elevating blood pressure | PMID: 15668387 |
| Obesity | PRCP modulates α-MSH processing; altered activity linked to metabolic dysregulation | PMID: 21159798 |
| Inflammatory disorders | PRCP cleaves bradykinin and other peptides, influencing vascular permeability and inflammation | PMID: 16478980 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Lung | 6.1 | Low |
| Heart | 4.7 | Low |
| Brain | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression in transfected cells |
| HepG2 | 9.8 | Endogenous expression |
| A549 | 5.4 | Moderate expression |
| K562 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | Rare | Reduced enzymatic activity in vitro |
| c.1523G>A (p.Arg508Gln) | Missense | Rare | Unknown functional effect |
| c.1-?_*_del | Deletion | Very rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense variants like p.Arg349Trp reduce catalytic activity; complete loss expected from deletions.
Gain of Function (GOF)
No gain-of-function mutations reported in PRCP.
Dominant Negative (DN)
No dominant-negative mechanisms described for PRCP.
View complete mutation data：
Gene Ontology (GO)
| • serine-type carboxypeptidase activity (GO:0004185) | • lysosome (GO:0005764) |
| • proteolysis (GO:0006508) | • angiotensin maturation (GO:0002003) |
| • extracellular region (GO:0005576) |
Pathways
• Renin-angiotensin system (RAS)
• Bradykinin degradation pathway
• Proopiomelanocortin (POMC) processing
Protein Summary
Prolylcarboxypeptidase (PCP) is a 58 kDa lysosomal serine protease that removes C-terminal amino acids from peptides with a penultimate proline. It is widely expressed in kidney, liver, and lung. PCP cleaves angiotensin II to angiotensin-(1-7), bradykinin, and α-MSH, thereby regulating blood pressure, inflammation, and energy homeostasis. Mutations are rare but may contribute to hypertension and metabolic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRCP Knockout HEK293 Cell Line | EDJ-KQ5527 | Human | 5547 | Details Get a Quote |
| PRCP Knockout HCT 116 Cell Line | EDJ-KQ27523 | Human | 5547 | Details Get a Quote |
| PRCP Knockout A-549 Cell Line | EDJ-KQ28772 | Human | 5547 | Details Get a Quote |
| PRCP Knockout HeLa Cell Line | EDJ-KQ28774 | Human | 5547 | Details Get a Quote |
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