PPM1B: Protein Phosphatase, Mg2+/Mn2+ Dependent 1B
A key regulator of cellular signaling through dephosphorylation of serine/threonine residues.
Gene Information Card
| Symbol | PPM1B |
|---|---|
| Full Name | Protein Phosphatase, Mg2+/Mn2+ Dependent 1B |
| Gene Type | Protein coding |
| Chromosomal Location | 2p21 |
| NCBI Gene ID | 5494 ncbi.nlm.nih.gov/gene/5494 |
| Ensembl ID | ENSG00000138032 |
| UniProt ID | O75688 |
| OMIM ID | 603310 |
| HGNC ID | 9277 |
| Aliases | PP2C-beta, PP2CB, PPM1B-beta |
Description
PPM1B encodes a member of the PP2C family of serine/threonine phosphatases. The enzyme is magnesium or manganese dependent and negatively regulates stress-activated MAP kinase pathways by dephosphorylating components such as p38 and JNK. It also modulates cell cycle progression, apoptosis, and insulin signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Dysregulation of PPM1B expression or activity alters MAPK signaling, promoting uncontrolled proliferation. | COSMIC; literature |
| Type 2 diabetes | PPM1B dephosphorylates AMPK and insulin signaling intermediates, affecting glucose metabolism. | OMIM; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 8.9 | Medium |
| Brain | 6.3 | Low |
| Skeletal Muscle | 15.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.3 | High expression |
| HeLa | 11.7 | Moderate expression |
| HepG2 | 13.0 | High expression |
| K562 | 9.5 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Potential loss of phosphatase activity |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the catalytic domain may reduce phosphatase activity, leading to sustained MAPK signaling.
Gain of Function (GOF)
Not well documented; overexpression in some cancers may enhance dephosphorylation of tumor suppressors.
Dominant Negative (DN)
Not reported for PPM1B.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine phosphatase activity (GO:0004722) | • protein dephosphorylation (GO:0006470) |
| • cytoplasm (GO:0005737) | • nucleus (GO:0005634) |
| • metal ion binding (GO:0046872) |
Pathways
• MAPK signaling pathway (hsa04010)
• Insulin signaling pathway (hsa04910)
• AMPK signaling pathway (hsa04152)
Protein Summary
PPM1B is a 479-amino acid protein with a conserved PP2C catalytic domain. It requires Mg2+ or Mn2+ for activity. The enzyme dephosphorylates key signaling proteins, including p38, JNK, AMPK, and components of the insulin cascade, thereby modulating stress responses, metabolism, and cell growth.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPM1B Knockout HEK293 Cell Line | EDJ-KQ732 | Human | 5495 | Details Get a Quote |
| PPM1B Knockout A-549 Cell Line | EDJ-KQ19356 | Human | 5495 | Details Get a Quote |
| PPM1B Knockout HCT 116 Cell Line | EDJ-KQ19357 | Human | 5495 | Details Get a Quote |
| PPM1B Knockout HeLa Cell Line | EDJ-KQ19358 | Human | 5495 | Details Get a Quote |
