PLXNB2: Plexin B2
A transmembrane semaphorin receptor involved in axon guidance, immune regulation, and cancer progression
Gene Information Card
| Symbol | PLXNB2 |
|---|---|
| Full Name | plexin B2 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.33 |
| NCBI Gene ID | 23654 ncbi.nlm.nih.gov/gene/23654 |
| Ensembl ID | ENSG00000100290 |
| UniProt ID | O15031 |
| OMIM ID | 604293 |
| HGNC ID | 9104 |
| Aliases | MM1, PLEXB2, SEMAPHORIN RECEPTOR |
Description
PLXNB2 encodes plexin B2, a transmembrane receptor for class 4 semaphorins. It plays critical roles in axon guidance, cell migration, immune response modulation, and tumor progression. The protein interacts with Rho family GTPases to regulate cytoskeletal dynamics and signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | PLXNB2 overexpression or mutation promotes tumor cell migration and invasion via semaphorin signaling | COSMIC, PubMed |
| Immune dysregulation | PLXNB2 modulates dendritic cell and T-cell function through semaphorin 4A/4D binding | PubMed |
| Neurodevelopmental disorders | Altered PLXNB2 signaling may affect axon guidance and neuronal connectivity | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Lung | 8.7 | Low |
| Kidney | 6.5 | Low |
| Liver | 4.2 | Low |
| Testis | 15.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Embryonic kidney |
| A549 | 7.2 | Lung carcinoma |
| MCF7 | 5.1 | Breast carcinoma |
| HepG2 | 3.9 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Altered semaphorin binding |
| c.2567A>G (p.Asn856Ser) | Missense | <0.1% | Unknown functional impact |
| c.3456_3457insA | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein or disrupt the semaphorin-binding domain.
Gain of Function (GOF)
Missense mutations that enhance receptor signaling or ligand affinity, potentially promoting oncogenic pathways.
Dominant Negative (DN)
Mutations that produce a truncated receptor interfering with wild-type plexin B2 function.
View complete mutation data：
Gene Ontology (GO)
| • semaphorin receptor activity | • axon guidance |
| • cell migration | • Rho GTPase binding |
| • signal transduction | • nervous system development |
Pathways
• Semaphorin signaling
• Axon guidance
• Rho GTPase cycle
• Cancer pathways
Protein Summary
Plexin B2 is a 1,838-amino-acid transmembrane protein with an extracellular semaphorin-binding domain, a single transmembrane helix, and a cytoplasmic region containing a GTPase-activating protein (GAP) domain. It mediates repulsive axon guidance, regulates immune cell interactions, and influences tumor cell invasiveness.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLXNB2 Knockout HEK293 Cell Line | EDJ-KQ8112 | Human | 23654 | Details Get a Quote |
| PLXNB2 Knockout A-549 Cell Line | EDJ-KQ33989 | Human | 23654 | Details Get a Quote |
| PLXNB2 Knockout HCT 116 Cell Line | EDJ-KQ33990 | Human | 23654 | Details Get a Quote |
| PLXNB2 Knockout HeLa Cell Line | EDJ-KQ33991 | Human | 23654 | Details Get a Quote |
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