PLXNA2
Plexin A2: A Semaphorin Receptor Involved in Axonal Guidance and Cancer
Gene Information Card
| Symbol | PLXNA2 |
|---|---|
| Full Name | plexin A2 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.2 |
| NCBI Gene ID | 5362 ncbi.nlm.nih.gov/gene/5362 |
| Ensembl ID | ENSG00000176399 |
| UniProt ID | O75051 |
| OMIM ID | 601054 |
| HGNC ID | 9101 |
| Aliases | PLXN2, KIAA0463, OCT, Plexin-A2 |
Description
PLXNA2 encodes plexin A2, a transmembrane receptor for class 3 semaphorins. It plays a critical role in axon guidance, neuronal migration, and immune cell regulation. Plexin A2 forms a complex with neuropilins and mediates repulsive signaling. Dysregulation of PLXNA2 is associated with neurodevelopmental disorders and various cancers, including breast, lung, and colorectal cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | PLXNA2 overexpression promotes cell migration and invasion via semaphorin signaling | PMID: 25605274 |
| Colorectal Cancer | PLXNA2 amplification correlates with poor prognosis and metastasis | PMID: 29187737 |
| Lung Adenocarcinoma | PLXNA2 upregulation associated with epithelial-mesenchymal transition | PMID: 30936319 |
| Schizophrenia | Genetic variants in PLXNA2 linked to increased risk | PMID: 17903249 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.1 | Low |
| Colon | 4.7 | Low |
| Kidney | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast cancer) | 15.2 | Moderate expression |
| A549 (Lung cancer) | 9.8 | Low expression |
| HCT116 (Colorectal cancer) | 7.5 | Low expression |
| HEK293 (Embryonic kidney) | 2.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.2150A>G (p.Asn717Ser) | Missense | <0.01% | Unknown functional impact |
| c.304C>T (p.Arg102Trp) | Missense | <0.01% | Possible loss of function |
| c.1234_1235insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the protein, impairing semaphorin binding and signaling.
Gain of Function (GOF)
Not well characterized; some missense variants may enhance receptor activity.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • semaphorin receptor activity | • axon guidance |
| • cell migration | • signal transduction |
| • plasma membrane |
Pathways
• Semaphorin signaling
• Axon guidance
• Neuropilin-plexin signaling
Protein Summary
Plexin A2 is a 1894-amino acid transmembrane protein with an extracellular Sema domain, PSI domains, and an intracellular GTPase-activating protein (GAP) domain. It binds semaphorin 3A/3F via neuropilin co-receptors, triggering cytoskeletal rearrangement and repulsive axon guidance. In cancer, PLXNA2 can promote invasive behavior.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLXNA2 Knockout HEK293 Cell Line | EDJ-KQ5486 | Human | 5362 | Details Get a Quote |
| PLXNA2 Knockout HeLa Cell Line | EDJ-KQ28711 | Human | 5362 | Details Get a Quote |
| PLXNA2 Knockout A-549 Cell Line | EDJ-KQ62656 | Human | 5362 | Details Get a Quote |
| PLXNA2 Knockout HCT 116 Cell Line | EDJ-KQ71123 | Human | 5362 | Details Get a Quote |
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