PLSCR2: Phospholipid Scramblase 2
A calcium-dependent phospholipid scramblase involved in membrane dynamics and potential roles in cancer and viral infection.
Gene Information Card
| Symbol | PLSCR2 |
|---|---|
| Full Name | Phospholipid Scramblase 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 3q24 |
| NCBI Gene ID | 57047 ncbi.nlm.nih.gov/gene/57047 |
| Ensembl ID | ENSG00000163823 |
| UniProt ID | Q9NRY7 |
| OMIM ID | 607610 |
| HGNC ID | 16493 |
| Aliases | PL scramblase 2, Ca(2+)-dependent phospholipid scramblase 2 |
Description
PLSCR2 encodes phospholipid scramblase 2, a member of the phospholipid scramblase family. This calcium-dependent protein mediates the bidirectional movement of phospholipids across the plasma membrane, disrupting membrane asymmetry. It is involved in cell signaling, apoptosis, and membrane remodeling. PLSCR2 is expressed in multiple tissues and has been implicated in cancer progression and viral entry processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may affect membrane dynamics and apoptotic signaling, contributing to tumor progression. | COSMIC; literature |
| Viral infections (e.g., SARS-CoV-2) | Potential role in viral entry by modulating membrane phospholipid exposure. | UniProt; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 8.2 | Low |
| Spleen | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.5 | Embryonic kidney cells |
| A549 | 7.8 | Lung carcinoma cells |
| HepG2 | 5.2 | Hepatocellular carcinoma cells |
| K562 | 4.1 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown functional effect; rare population variant |
| c.682G>A (p.Glu228Lys) | Missense | <0.01% | Unknown functional effect; rare population variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0017128 (phospholipid scramblase activity) | • GO:0005509 (calcium ion binding) |
| • GO:0005886 (plasma membrane) | • GO:0005548 (phospholipid transporter activity) |
| • GO:0006915 (apoptotic process) |
Pathways
• Phospholipid scrambling (Reactome: R-HSA-1483257)
• Apoptosis (KEGG: hsa04210)
Protein Summary
Phospholipid scramblase 2 (PLSCR2) is a 37 kDa protein that localizes to the plasma membrane and endoplasmic reticulum. It contains a calcium-binding EF-hand domain and a conserved scramblase domain. Upon calcium activation, PLSCR2 facilitates rapid transbilayer movement of phospholipids, collapsing membrane asymmetry. This activity is critical for processes such as cell activation, apoptosis, and viral entry. PLSCR2 is expressed in testis, lung, and other tissues, with lower levels in brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLSCR2 Knockout HEK293 Cell Line | EDJ-KQ14809 | Human | 57047 | Details Get a Quote |
| PLSCR2 Knockout HeLa Cell Line | EDJ-KQ56791 | Human | 57047 | Details Get a Quote |
| PLSCR2 Knockout A-549 Cell Line | EDJ-KQ65297 | Human | 57047 | Details Get a Quote |
| PLSCR2 Knockout HCT 116 Cell Line | EDJ-KQ73738 | Human | 57047 | Details Get a Quote |
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