PLG Gene (Plasminogen)
Key regulator of fibrinolysis and extracellular matrix remodeling
Gene Information Card
| Symbol | PLG |
|---|---|
| Full Name | Plasminogen |
| Gene Type | protein-coding |
| Chromosomal Location | 6q26 |
| NCBI Gene ID | 5340 ncbi.nlm.nih.gov/gene/5340 |
| Ensembl ID | ENSG00000122194 |
| UniProt ID | P00747 |
| OMIM ID | 173350 |
| HGNC ID | 9071 |
| Aliases | PLG, plasminogen |
Description
The PLG gene encodes plasminogen, a circulating zymogen that is converted to plasmin, a serine protease that degrades fibrin clots and extracellular matrix components. Plasminogen plays a central role in fibrinolysis, tissue remodeling, cell migration, and wound healing. Mutations in PLG cause plasminogen deficiency, leading to ligneous conjunctivitis and thrombosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ligneous conjunctivitis | Deficiency of plasminogen leads to impaired fibrinolysis and accumulation of fibrin-rich pseudomembranes on mucous membranes. | ClinVar, OMIM |
| Plasminogen deficiency, type I (hypoplasminogenemia) | Loss-of-function mutations reduce plasminogen activity, causing thrombotic and mucosal lesions. | ClinVar, OMIM |
| Thrombophilia | Reduced plasminogen activity predisposes to venous thrombosis. | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Kidney | 3.2 | Medium |
| Lung | 1.8 | Low |
| Heart | 0.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocyte cell line, high expression |
| HEK293 | 2.1 | Low expression |
| A549 | 1.5 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.2125G>A (p.Gly709Arg) | Missense | Rare | Reduced plasminogen activity |
| c.112A>G (p.Lys38Glu) | Missense | Rare | Impaired secretion |
| c.1468C>T (p.Arg490Cys) | Missense | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Most PLG mutations are loss-of-function, reducing plasminogen activity or secretion.
Gain of Function (GOF)
Not reported for PLG.
Dominant Negative (DN)
Not reported for PLG.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Plasminogen activating cascade (Reactome: R-HSA-75205)
• Fibrinolysis (KEGG: hsa04610)
Protein Summary
Plasminogen is a 791-amino-acid glycoprotein synthesized primarily in the liver. It contains five kringle domains and a serine protease domain. Upon activation by tissue-type plasminogen activator (tPA) or urokinase, it is converted to plasmin, which degrades fibrin clots and extracellular matrix proteins. Plasminogen also regulates cell migration and wound healing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLG Knockout HEK293 Cell Line | EDJ-KQ3711 | Human | 5340 | Details Get a Quote |
| PLGRKT Knockout HEK293 Cell Line | EDJ-KQ14803 | Human | 55848 | Details Get a Quote |
| PLGRKT Knockout HeLa Cell Line | EDJ-KQ43968 | Human | 55848 | Details Get a Quote |
| PLG Knockout HeLa Cell Line | EDJ-KQ24373 | Human | 5340 | Details Get a Quote |
| PLG Knockout A-549 Cell Line | EDJ-KQ25743 | Human | 5340 | Details Get a Quote |
| PLGRKT Knockout A-549 Cell Line | EDJ-KQ45227 | Human | 55848 | Details Get a Quote |
| PLGRKT Knockout HCT 116 Cell Line | EDJ-KQ45228 | Human | 55848 | Details Get a Quote |
| PLGLB2 Knockout HEK293 Cell Line | EDJ-KQ50516 | Human | 5342 | Details Get a Quote |
| PLGLB1 Knockout HEK293 Cell Line | EDJ-KQ50517 | Human | 5343 | Details Get a Quote |
| SELPLG Knockout HEK293 Cell Line | EDJ-KQ50621 | Human | 6404 | Details Get a Quote |
| PLGLB2 Knockout HeLa Cell Line | EDJ-KQ54154 | Human | 5342 | Details Get a Quote |
| PLGLB1 Knockout HeLa Cell Line | EDJ-KQ54155 | Human | 5343 | Details Get a Quote |
| SELPLG Knockout HeLa Cell Line | EDJ-KQ54441 | Human | 6404 | Details Get a Quote |
| PLGLB2 Knockout A-549 Cell Line | EDJ-KQ62649 | Human | 5342 | Details Get a Quote |
| PLGLB1 Knockout A-549 Cell Line | EDJ-KQ62650 | Human | 5343 | Details Get a Quote |
Displaying Records 1 To 15 Of 20 Records
