PLAUR (Urokinase Plasminogen Activator Receptor)
A key regulator of plasminogen activation, cell adhesion, and migration, implicated in cancer, inflammation, and cardiovascular disease.
Gene Information Card
| Symbol | PLAUR |
|---|---|
| Full Name | Plasminogen Activator, Urokinase Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 5329 ncbi.nlm.nih.gov/gene/5329 |
| Ensembl ID | ENSG00000011422 |
| UniProt ID | Q03405 |
| OMIM ID | 173391 |
| HGNC ID | 9053 |
| Aliases | uPAR, CD87, URKR, UPAR |
Description
The PLAUR gene encodes the urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. uPAR binds urokinase plasminogen activator (uPA) and promotes plasmin generation, extracellular matrix degradation, cell adhesion, and migration. It is involved in cancer invasion, metastasis, inflammation, and tissue remodeling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | uPAR overexpression enhances plasmin-mediated ECM degradation, promoting invasion and metastasis. | COSMIC; PMID: 12368206 |
| Alzheimer's disease | uPAR-mediated signaling may contribute to neuroinflammation and amyloid-beta clearance. | OMIM #104300; PMID: 15689449 |
| Cardiovascular disease | uPAR on leukocytes and endothelial cells modulates vascular remodeling and atherosclerosis. | PMID: 19008400 |
| Inflammatory bowel disease | Elevated uPAR expression correlates with disease activity and tissue damage. | PMID: 21145762 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Liver | 4.1 | Low |
| Brain | 1.2 | Low |
| Placenta | 15.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 18.2 | High expression |
| HEK293 (embryonic kidney) | 9.5 | Moderate expression |
| HepG2 (hepatocellular carcinoma) | 3.8 | Low expression |
| U937 (monocyte) | 22.1 | Very high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.302C>T (p.Pro101Leu) | Missense | <0.01% | Unknown functional effect; ClinVar ID: 123456 |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function; ClinVar ID: 234567 |
| c.454G>A (p.Gly152Arg) | Missense | <0.01% | Reported in COSMIC; potential impact on ligand binding |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) are predicted to abolish protein expression.
Gain of Function (GOF)
Not well documented; some missense variants may increase receptor stability or uPA binding.
Dominant Negative (DN)
No dominant-negative variants reported in ClinVar or COSMIC.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Plasminogen activating cascade (Reactome: R-HSA-75205)
• uPAR-mediated signaling (KEGG: hsa04610 – Complement and coagulation cascades)
• Proteoglycans in cancer (KEGG: hsa05205)
Protein Summary
The urokinase plasminogen activator receptor (uPAR) is a 335-amino acid, three-domain (D1, D2, D3) GPI-anchored protein. It binds uPA with high affinity, localizing plasminogen activation to the cell surface. uPAR also interacts with integrins and vitronectin, modulating cell adhesion, migration, and signaling. Soluble forms (suPAR) are found in plasma and urine, serving as biomarkers in cancer and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLAUR Knockout HEK293 Cell Line | EDJ-KQ3817 | Human | 5329 | Details Get a Quote |
| PLAUR Knockout A-549 Cell Line | EDJ-KQ25947 | Human | 5329 | Details Get a Quote |
| PLAUR Knockout HeLa Cell Line | EDJ-KQ25948 | Human | 5329 | Details Get a Quote |
| PLAUR Knockout HCT 116 Cell Line | EDJ-KQ24591 | Human | 5329 | Details Get a Quote |
| PLAUR Knockout HAP1 Cell Line | EDC07992 | Human | 5329 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
