PLA1A: Phospholipase A1 Member A
Gene encoding a phospholipase A1 enzyme involved in lipid metabolism and potential roles in cancer and inflammation
Gene Information Card
| Symbol | PLA1A |
|---|---|
| Full Name | Phospholipase A1 Member A |
| Gene Type | protein-coding |
| Chromosomal Location | 3q13.2 |
| NCBI Gene ID | 51365 ncbi.nlm.nih.gov/gene/51365 |
| Ensembl ID | ENSG00000144837 |
| UniProt ID | Q53H76 |
| OMIM ID | 607144 |
| HGNC ID | 17661 |
| Aliases | PS-PLA1, PLA1, mPA-PLA1, phosphatidylserine-specific phospholipase A1 |
Description
PLA1A encodes a phospholipase A1 enzyme that specifically hydrolyzes phosphatidylserine to produce 2-acyl-lysophosphatidylserine and fatty acids. This enzyme is involved in lipid metabolism and signaling, and its expression is associated with various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered lipid metabolism and signaling through lysophosphatidylserine production | PMID: 23455478 |
| Inflammatory diseases | Modulation of immune cell activation via lysophospholipid mediators | PMID: 19028676 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 8.2 | Low |
| Spleen | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 15.2 | High expression |
| HepG2 (liver cancer) | 7.8 | Moderate expression |
| K562 (leukemia) | 5.1 | Low expression |
| MCF7 (breast cancer) | 4.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown functional effect |
| c.1246G>A (p.Gly416Arg) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phosphatidylserine 1-acylhydrolase activity (GO:0008970) | • lipid metabolic process (GO:0006629) |
| • plasma membrane (GO:0005886) | • lipid catabolic process (GO:0016042) |
Pathways
• Lysophospholipid signaling (Reactome: R-HSA-428157)
• Glycerophospholipid metabolism (KEGG: hsa00564)
Protein Summary
PLA1A is a 456-amino acid protein with a molecular weight of approximately 51 kDa. It contains a phospholipase A1 catalytic domain and is localized to the plasma membrane. The enzyme specifically cleaves phosphatidylserine to generate lysophosphatidylserine, a bioactive lipid that modulates immune cell function and cancer cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA1A Knockout HEK293 Cell Line | EDJ-KQ1256 | Human | 51365 | Details Get a Quote |
| PLA1A Knockout HeLa Cell Line | EDJ-KQ56298 | Human | 51365 | Details Get a Quote |
| PLA1A Knockout A-549 Cell Line | EDJ-KQ64787 | Human | 51365 | Details Get a Quote |
| PLA1A Knockout HCT 116 Cell Line | EDJ-KQ73233 | Human | 51365 | Details Get a Quote |
