PIMREG (PICALM Interacting Mitotic Regulator)
A cell cycle regulator involved in mitosis and cancer progression
Gene Information Card
| Symbol | PIMREG |
|---|---|
| Full Name | PICALM interacting mitotic regulator |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.2 |
| NCBI Gene ID | 54433 ncbi.nlm.nih.gov/gene/54433 |
| Ensembl ID | ENSG00000108848 |
| UniProt ID | Q96S55 |
| OMIM ID | 617620 |
| HGNC ID | 25922 |
| Aliases | C17orf49, FAM64A, RCS1 |
Description
PIMREG (PICALM interacting mitotic regulator) is a protein-coding gene that encodes a regulator of mitotic progression. It interacts with PICALM and is involved in cell cycle control, particularly during mitosis. Overexpression of PIMREG has been observed in various cancers and is associated with poor prognosis, suggesting a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and mitotic progression | PMID: 31591470 |
| Lung adenocarcinoma | Upregulation correlates with poor survival and immune infiltration | PMID: 32665974 |
| Colorectal cancer | High expression linked to tumor growth and metastasis | PMID: 31270520 |
| Acute myeloid leukemia | Fusion with PICALM (CALM-AF10) drives leukemogenesis | PMID: 10655551 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Testis | 6.7 | Low |
| Spleen | 5.1 | Low |
| Thymus | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 10.1 | Moderate expression |
| K562 | 8.5 | Moderate expression |
| MCF7 | 7.3 | Low expression |
| A549 | 6.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact |
| c.454G>A (p.Val152Met) | Missense | <0.01% | Unknown functional impact |
| CALM-PIMREG fusion | Structural variant | Rare | Oncogenic; drives leukemia |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in promoting mitosis.
Dominant Negative (DN)
No evidence of dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • Mitotic cell cycle | • Cell division |
| • Regulation of mitotic nuclear division | • Protein binding |
| • Nucleus |
Pathways
• Cell cycle
• Mitotic prometaphase
Protein Summary
The PIMREG protein is a nuclear protein that localizes to the mitotic spindle and centrosomes. It regulates mitotic progression by interacting with PICALM and other cell cycle components. Its expression is cell cycle-dependent, peaking during G2/M phase. Overexpression in tumors suggests it may serve as a prognostic biomarker and therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PIMREG Knockout HEK293 Cell Line | EDJ-KQ3685 | Human | 54478 | Details Get a Quote |
| PIMREG Knockout HCT 116 Cell Line | EDJ-KQ24308 | Human | 54478 | Details Get a Quote |
| PIMREG Knockout A-549 Cell Line | EDJ-KQ25681 | Human | 54478 | Details Get a Quote |
| PIMREG Knockout HeLa Cell Line | EDJ-KQ25683 | Human | 54478 | Details Get a Quote |
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