PICK1 Gene (Protein Interacting with PRKCA 1)
A scaffold protein involved in synaptic plasticity, receptor trafficking, and cancer signaling.
Gene Information Card
| Symbol | PICK1 |
|---|---|
| Full Name | Protein Interacting With PRKCA 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q13.1 |
| NCBI Gene ID | 9463 ncbi.nlm.nih.gov/gene/9463 |
| Ensembl ID | ENSG00000100162 |
| UniProt ID | Q9NRD5 |
| OMIM ID | 605926 |
| HGNC ID | 9394 |
| Aliases | PRKCABP, MGC15204, PICK1 |
Description
PICK1 (Protein Interacting with PRKCA 1) encodes a PDZ domain-containing scaffold protein that binds to protein kinase C alpha (PRKCA) and various transmembrane receptors. It plays a critical role in synaptic plasticity by regulating AMPA receptor trafficking, and is implicated in cancer cell migration, neuronal signaling, and vesicle transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PICK1 overexpression promotes cell migration and invasion via PKCα signaling | COSMIC, PubMed |
| Lung cancer | PICK1 upregulation correlates with poor prognosis and metastasis | COSMIC, PubMed |
| Schizophrenia | PICK1 variants may alter AMPAR trafficking and synaptic function | ClinVar, OMIM |
| Epilepsy | Dysregulation of PICK1-mediated receptor internalization linked to seizure susceptibility | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.1 | Low |
| Testis | 15.2 | Medium |
| Liver | 4.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Moderate expression |
| MCF7 | 7.2 | Low expression |
| A549 | 11.4 | Moderate expression |
| SH-SY5Y | 14.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon |
| c.202C>T (p.Arg68Trp) | Missense | <0.01% | Unknown significance |
| c.415G>A (p.Gly139Ser) | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • PDZ domain binding (GO:0030165) |
| • modulation of chemical synaptic transmission (GO:0050804) | • synapse (GO:0045202) |
| • plasma membrane (GO:0005886) |
Pathways
• AMPAR trafficking (Reactome: R-HSA-399719)
• PKC-mediated signaling (Reactome: R-HSA-2122948)
Protein Summary
PICK1 is a 416-amino acid scaffold protein containing an N-terminal PDZ domain and a C-terminal coiled-coil region. It binds to the C-terminus of PRKCA and various receptors (e.g., AMPA receptors, mGluR7, dopamine transporter). Through these interactions, PICK1 regulates receptor clustering, internalization, and synaptic strength. It is widely expressed in brain and also in peripheral tissues, with roles in cancer cell motility.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PICK1 Knockout HEK293 Cell Line | EDJ-KQ14753 | Human | 9463 | Details Get a Quote |
| PICK1 Knockout HeLa Cell Line | EDJ-KQ18089 | Human | 9463 | Details Get a Quote |
| PICK1 Knockout HCT 116 Cell Line | EDJ-KQ18143 | Human | 9463 | Details Get a Quote |
| PICK1 Knockout A-549 Cell Line | EDJ-KQ45127 | Human | 9463 | Details Get a Quote |
