PGRMC2
Progesterone Receptor Membrane Component 2
Gene Information Card
| Symbol | PGRMC2 |
|---|---|
| Full Name | Progesterone Receptor Membrane Component 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q28.2 |
| NCBI Gene ID | 10424 ncbi.nlm.nih.gov/gene/10424 |
| Ensembl ID | ENSG00000164040 |
| UniProt ID | O15173 |
| OMIM ID | 607735 |
| HGNC ID | 8909 |
| Aliases | DG6, PMBP |
Description
PGRMC2 (progesterone receptor membrane component 2) is a protein-coding gene located on chromosome 4q28.2. It encodes a membrane-associated progesterone receptor that binds progesterone and is involved in various cellular processes including steroid hormone signaling, cell survival, and metabolism. The protein is a member of the membrane-associated progesterone receptor (MAPR) family and contains a cytochrome b5-like heme/steroid-binding domain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (breast, ovarian, endometrial) | PGRMC2 overexpression may promote cell proliferation and resistance to apoptosis via progesterone signaling pathways. | NCBI Gene, UniProt |
| Metabolic disorders (obesity, insulin resistance) | PGRMC2 modulates lipid metabolism and insulin sensitivity through interaction with progesterone and other ligands. | UniProt, PubMed |
| Neurological disorders | Potential role in neurosteroid signaling and neuroprotection, but evidence is limited. | UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 8.1 | Low |
| Brain | 6.4 | Low |
| Lung | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HeLa | 7.2 | Cervical cancer cell line |
| HEK293 | 6.5 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347C>T (p.Thr116Met) | missense | <0.01% | Unknown functional impact; rare variant in population databases |
| c.512A>G (p.Asn171Ser) | missense | <0.01% | Unknown functional impact; rare variant in population databases |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PGRMC2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PGRMC2.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in PGRMC2.
View complete mutation data：
Gene Ontology (GO)
| • progesterone binding | • heme binding |
| • steroid binding | • membrane |
| • endoplasmic reticulum | • nucleus |
| • signal transduction | • cell proliferation |
Pathways
• Progesterone signaling pathway
• Steroid hormone biosynthesis
Protein Summary
PGRMC2 encodes a 223-amino acid protein (UniProt O15173) that is a membrane-associated progesterone receptor. It contains a cytochrome b5-like domain that binds heme and steroids, particularly progesterone. The protein localizes to the endoplasmic reticulum and plasma membrane, and is involved in progesterone-mediated signaling, cell survival, and metabolic regulation. It is expressed in multiple tissues including liver, kidney, and heart.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGRMC2 Knockout HEK293 Cell Line | EDJ-KQ7042 | Human | 10424 | Details Get a Quote |
| PGRMC2 Knockout A-549 Cell Line | EDJ-KQ31809 | Human | 10424 | Details Get a Quote |
| PGRMC2 Knockout HCT 116 Cell Line | EDJ-KQ31810 | Human | 10424 | Details Get a Quote |
| PGRMC2 Knockout HeLa Cell Line | EDJ-KQ31811 | Human | 10424 | Details Get a Quote |
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