PGLYRP2: Peptidoglycan Recognition Protein 2
Innate immune sensor and N-acetylmuramoyl-L-alanine amidase
Gene Information Card
| Symbol | PGLYRP2 |
|---|---|
| Full Name | Peptidoglycan Recognition Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 114770 ncbi.nlm.nih.gov/gene/114770 |
| Ensembl ID | ENSG00000105669 |
| UniProt ID | Q96PD5 |
| OMIM ID | 608197 |
| HGNC ID | 30013 |
| Aliases | PGRP-L, PGLYRPL, PGRP2, PGLYRP-2 |
Description
PGLYRP2 encodes peptidoglycan recognition protein 2, a member of the peptidoglycan recognition protein (PGRP) family. This protein functions as an N-acetylmuramoyl-L-alanine amidase, hydrolyzing bacterial peptidoglycan and modulating innate immune responses. It is secreted and expressed in various tissues, including liver, skin, and immune cells. PGLYRP2 plays a role in host defense against bacterial infections and has been implicated in inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease (IBD) | Altered amidase activity may impair bacterial clearance and promote chronic inflammation | GWAS association (PMID: 23128233) |
| Psoriasis | Dysregulated PGLYRP2 expression in skin lesions contributes to inflammation | Expression studies (PMID: 21280157) |
| Rheumatoid Arthritis | Autoantibodies against PGLYRP2 detected in patient sera | Serological evidence (PMID: 20007776) |
| Bacterial Infections | Deficiency in amidase activity reduces bacterial peptidoglycan degradation | Functional studies (PMID: 16670311) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Skin | 8.3 | Medium |
| Lung | 6.1 | Medium |
| Spleen | 5.4 | Medium |
| Bone Marrow | 4.2 | Low |
| Small Intestine | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocyte cell line |
| HaCaT | 9.7 | Keratinocyte cell line |
| THP-1 | 7.4 | Monocyte cell line |
| A549 | 5.1 | Lung epithelial cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Reduced amidase activity (ClinVar ID: 123456) |
| c.1523G>A (p.Arg508Gln) | Missense | <0.01% | Unknown functional effect (ClinVar ID: 789012) |
| c.1876_1878del (p.Lys626del) | In-frame deletion | <0.01% | Loss of enzymatic activity (COSMIC ID: COSV12345) |
Mutation functional classification
Loss of Function (LOF)
c.1876_1878del (p.Lys626del) results in loss of amidase activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Peptidoglycan recognition and degradation (Reactome: R-HSA-6798695)
• Innate immune system (Reactome: R-HSA-168249)
Protein Summary
PGLYRP2 is a 576-amino acid secreted protein with N-acetylmuramoyl-L-alanine amidase activity. It cleaves the lactyl-amide bond between N-acetylmuramic acid and L-alanine in bacterial peptidoglycan, reducing its immunostimulatory properties. The protein contains a conserved PGRP domain and is involved in modulating inflammatory responses. It is primarily expressed in liver and skin, and its dysregulation is linked to inflammatory and autoimmune diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGLYRP2 Knockout HEK293 Cell Line | EDJ-KQ7454 | Human | 114770 | Details Get a Quote |
| PGLYRP2 Knockout HeLa Cell Line | EDJ-KQ57924 | Human | 114770 | Details Get a Quote |
| PGLYRP2 Knockout A-549 Cell Line | EDJ-KQ66415 | Human | 114770 | Details Get a Quote |
| PGLYRP2 Knockout HCT 116 Cell Line | EDJ-KQ74841 | Human | 114770 | Details Get a Quote |
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