PGLYRP1
Peptidoglycan Recognition Protein 1
Gene Information Card
| Symbol | PGLYRP1 |
|---|---|
| Full Name | Peptidoglycan Recognition Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 8993 ncbi.nlm.nih.gov/gene/8993 |
| Ensembl ID | ENSG00000105639 |
| UniProt ID | O75594 |
| OMIM ID | 604074 |
| HGNC ID | 8904 |
| Aliases | PGRP, PGRP-S, PGLYRP, TNFSF3L |
Description
PGLYRP1 encodes peptidoglycan recognition protein 1, a member of the peptidoglycan recognition protein (PGRP) family. This protein is involved in innate immunity by binding to bacterial peptidoglycan and triggering antibacterial responses. It is primarily expressed in neutrophils and plays a role in host defense against Gram-positive and Gram-negative bacteria.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Periodontitis | Altered PGLYRP1 expression may impair bacterial clearance in oral mucosa, contributing to chronic inflammation. | PMID: 20624719 |
| Inflammatory Bowel Disease (IBD) | Dysregulation of PGLYRP1 in intestinal epithelium may affect microbiome sensing and immune homeostasis. | PMID: 23222558 |
| Bacterial Infections | PGLYRP1 deficiency reduces bactericidal activity against Staphylococcus aureus and Escherichia coli. | PMID: 16940119 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | High |
| Spleen | 8.3 | Medium |
| Lung | 5.1 | Medium |
| Small Intestine | 3.2 | Low |
| Colon | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (promyeloblast) | 15.2 | High expression; neutrophil-like differentiation |
| K-562 (leukemia) | 4.7 | Moderate expression |
| HeLa (cervical) | 0.8 | Low expression |
| A549 (lung) | 1.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | May affect peptidoglycan binding; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Mutations disrupting the start codon or peptidoglycan-binding domain are predicted to reduce or abolish antibacterial activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Innate Immune System (Reactome: R-HSA-168249)
• Peptidoglycan recognition and signaling (Reactome: R-HSA-6798695)
Protein Summary
PGLYRP1 is a 196-amino acid secreted protein containing a single peptidoglycan-binding domain (PGRP domain). It is stored in neutrophil granules and released upon activation. The protein directly binds bacterial peptidoglycan, inducing bacterial cell wall damage and promoting phagocytosis. It also modulates inflammatory responses by interacting with pattern recognition receptors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGLYRP1 Knockout HEK293 Cell Line | EDJ-KQ6424 | Human | 8993 | Details Get a Quote |
| PGLYRP1 Knockout HeLa Cell Line | EDJ-KQ55050 | Human | 8993 | Details Get a Quote |
| PGLYRP1 Knockout A-549 Cell Line | EDJ-KQ63533 | Human | 8993 | Details Get a Quote |
| PGLYRP1 Knockout HCT 116 Cell Line | EDJ-KQ72003 | Human | 8993 | Details Get a Quote |
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