PEBP4
Phosphatidylethanolamine-Binding Protein 4
Gene Information Card
| Symbol | PEBP4 |
|---|---|
| Full Name | Phosphatidylethanolamine-Binding Protein 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p21.3 |
| NCBI Gene ID | 157310 ncbi.nlm.nih.gov/gene/157310 |
| Ensembl ID | ENSG00000164741 |
| UniProt ID | Q96S96 |
| OMIM ID | 617677 |
| HGNC ID | 28302 |
| Aliases | CORK1, hPEBP4, PEBP-4 |
Description
PEBP4 (phosphatidylethanolamine-binding protein 4) is a member of the phosphatidylethanolamine-binding protein family. It is involved in the regulation of cell survival, apoptosis, and the MAPK signaling pathway. PEBP4 is overexpressed in several cancers and is associated with poor prognosis, acting as a negative regulator of apoptosis by inhibiting the Raf/MEK/ERK pathway.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of PEBP4 inhibits apoptosis via Raf/MEK/ERK pathway suppression, promoting tumor growth and metastasis. | PMID: 19029980 |
| Prostate Cancer | PEBP4 upregulation correlates with advanced disease and resistance to apoptosis. | PMID: 21444671 |
| Lung Cancer | Elevated PEBP4 expression associated with poor survival and enhanced metastatic potential. | PMID: 23429205 |
| Colorectal Cancer | PEBP4 promotes cell proliferation and invasion through ERK1/2 signaling. | PMID: 25634884 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 3.2 | Low |
| Liver | 1.8 | Low |
| Lung | 5.6 | Medium |
| Breast | 4.1 | Medium |
| Prostate | 6.3 | Medium |
| Colon | 7.0 | Medium |
| Ovary | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 8.2 | Overexpressed |
| PC3 (prostate cancer) | 9.1 | Overexpressed |
| A549 (lung cancer) | 7.5 | Overexpressed |
| HCT116 (colorectal cancer) | 6.8 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.1% (COSMIC) | Unknown functional impact |
| c.412C>T (p.Arg138Trp) | Missense | <0.1% (COSMIC) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • phosphatidylethanolamine binding (GO:0008428) | • negative regulation of apoptotic process (GO:0043066) |
| • MAPK cascade (GO:0000165) | • cytoplasm (GO:0005737) |
Pathways
• Raf/MEK/ERK signaling pathway
• Apoptosis regulation
Protein Summary
PEBP4 is a 227-amino-acid protein that binds phosphatidylethanolamine. It localizes to the cytoplasm and functions as a negative regulator of the Raf/MEK/ERK signaling cascade, thereby inhibiting apoptosis. Overexpression in various cancers contributes to tumor progression and therapy resistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PEBP4 Knockout HEK293 Cell Line | EDJ-KQ14724 | Human | 157310 | Details Get a Quote |
| PEBP4 Knockout HeLa Cell Line | EDJ-KQ58759 | Human | 157310 | Details Get a Quote |
| PEBP4 Knockout A-549 Cell Line | EDJ-KQ67243 | Human | 157310 | Details Get a Quote |
| PEBP4 Knockout HCT 116 Cell Line | EDJ-KQ75640 | Human | 157310 | Details Get a Quote |
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