PDE3B Gene: Phosphodiesterase 3B
A key regulator of cAMP/cGMP signaling in metabolic and cardiovascular health
Gene Information Card
| Symbol | PDE3B |
|---|---|
| Full Name | Phosphodiesterase 3B |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.1 |
| NCBI Gene ID | 5140 ncbi.nlm.nih.gov/gene/5140 |
| Ensembl ID | ENSG00000152270 |
| UniProt ID | Q13370 |
| OMIM ID | 602047 |
| HGNC ID | 8779 |
| Aliases | cGIPDE1, HcGIPDE1 |
Description
PDE3B encodes phosphodiesterase 3B, an enzyme that hydrolyzes cyclic AMP (cAMP) and cyclic GMP (cGMP), with higher affinity for cAMP. It plays a critical role in regulating intracellular cyclic nucleotide levels, influencing insulin signaling, lipolysis, and cardiac function. PDE3B is expressed in multiple tissues including adipose, liver, and heart, and is implicated in metabolic and cardiovascular diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes | Impaired insulin signaling due to altered PDE3B activity affects glucose homeostasis | PMID: 15616093 |
| Obesity | PDE3B regulates lipolysis; dysregulation contributes to adipocyte dysfunction | PMID: 21862674 |
| Heart Failure | PDE3B modulates cardiac contractility; inhibition is used therapeutically | PMID: 20585035 |
| Cancer | Altered PDE3B expression may influence tumor progression via cAMP signaling | PMID: 29463868 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose Tissue | High | High |
| Liver | Medium | Medium |
| Heart | Medium | Medium |
| Skeletal Muscle | Low | Low |
| Brain | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | Medium | Liver cancer cell line |
| 3T3-L1 | High | Adipocyte precursor |
| HL-1 | Medium | Cardiac muscle cell line |
| C2C12 | Low | Myoblast |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs7528153 | SNV | 0.15 (global) | Intronic; may affect splicing |
| rs7528153 | SNV | 0.15 (global) | Intronic; may affect splicing |
| rs7528153 | SNV | 0.15 (global) | Intronic; may affect splicing |
| rs7528153 | SNV | 0.15 (global) | Intronic; may affect splicing |
Mutation functional classification
Loss of Function (LOF)
Rare variants causing reduced PDE3B activity may impair insulin's anti-lipolytic effect, contributing to insulin resistance.
Gain of Function (GOF)
No clear gain-of-function mutations reported; overexpression in some cancers may enhance proliferation.
Dominant Negative (DN)
Not documented for PDE3B.
View complete mutation data：
Gene Ontology (GO)
| • 3' | • 5'-cyclic-AMP phosphodiesterase activity |
| • 5'-cyclic-GMP phosphodiesterase activity | • cAMP binding |
| • cGMP binding | • metal ion binding |
| • signal transduction | • insulin receptor signaling pathway |
| • negative regulation of cAMP-mediated signaling |
Pathways
• cAMP signaling pathway
• cGMP-PKG signaling pathway
• Insulin signaling pathway
• Adipocytokine signaling pathway
Protein Summary
PDE3B is a membrane-bound phosphodiesterase that preferentially hydrolyzes cAMP, thereby regulating intracellular cAMP levels. It is a key effector of insulin and leptin signaling, controlling lipolysis and glycogenolysis. In the heart, PDE3B contributes to contractility regulation. Its expression is tissue-specific, with high levels in adipose tissue and moderate levels in liver and heart. PDE3B is a therapeutic target for heart failure (e.g., milrinone) and is being explored for metabolic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PDE3B Knockout HEK293 Cell Line | EDJ-KQ1442 | Human | 5140 | Details Get a Quote |
| PDE3B Knockout HCT 116 Cell Line | EDJ-KQ20988 | Human | 5140 | Details Get a Quote |
| PDE3B Knockout HeLa Cell Line | EDJ-KQ20989 | Human | 5140 | Details Get a Quote |
| PDE3B Knockout A-549 Cell Line | EDJ-KQ19653 | Human | 5140 | Details Get a Quote |
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