PARP2: Poly(ADP-Ribose) Polymerase 2
A key DNA repair enzyme and therapeutic target in cancer and beyond
Gene Information Card
| Symbol | PARP2 |
|---|---|
| Full Name | Poly(ADP-Ribose) Polymerase 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 10038 ncbi.nlm.nih.gov/gene/10038 |
| Ensembl ID | ENSG00000129484 |
| UniProt ID | Q9UGN5 |
| OMIM ID | 607725 |
| HGNC ID | 272 |
| Aliases | ADPRT2, ADPRTL2, ARTD2, pADPRT-2 |
Description
PARP2 encodes poly(ADP-ribose) polymerase 2, a member of the PARP enzyme family that catalyzes poly(ADP-ribosyl)ation, a post-translational modification involved in DNA damage repair, particularly single-strand break repair and base excision repair. PARP2 is also implicated in transcriptional regulation, chromatin remodeling, and mitotic spindle function. It is a target for PARP inhibitors used in cancer therapy, especially in tumors with BRCA1/BRCA2 mutations.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PARP2 overexpression may contribute to DNA repair in tumor cells; PARP inhibitors exploit synthetic lethality in BRCA-deficient cancers | ClinVar, COSMIC |
| Ovarian cancer | Similar synthetic lethality mechanism; PARP2 inhibition enhances cytotoxicity in homologous recombination-deficient cells | ClinVar, COSMIC |
| Pancreatic cancer | PARP2 alterations may affect response to platinum-based chemotherapy and PARP inhibitors | COSMIC |
| Prostate cancer | PARP2 mutations and expression changes linked to DNA repair defects and therapeutic response | ClinVar, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 14.2 | Medium |
| Spleen | 11.5 | Medium |
| Bone marrow | 10.8 | Medium |
| Lymph node | 9.3 | Medium |
| Brain | 6.1 | Low |
| Heart | 5.4 | Low |
| Liver | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.1 | Cervical cancer cell line |
| K562 | 10.5 | Leukemia cell line |
| A549 | 9.8 | Lung cancer cell line |
| MCF7 | 8.3 | Breast cancer cell line |
| HEK293 | 7.6 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1129C>T (p.Arg377Ter) | Nonsense | Rare | Loss of function; truncation of catalytic domain |
| c.1487G>A (p.Arg496His) | Missense | Rare | Unknown; may affect catalytic activity |
| c.1655T>C (p.Ile552Thr) | Missense | Rare | Unknown; located in regulatory domain |
| c.1942A>G (p.Asn648Asp) | Missense | Rare | Unknown; potential impact on protein stability |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg377Ter) lead to truncated, non-functional PARP2 protein, impairing DNA repair.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in PARP2.
Dominant Negative (DN)
No dominant-negative mutations described for PARP2.
View complete mutation data：
Gene Ontology (GO)
| • NAD+ ADP-ribosyltransferase activity (GO:0003950) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • DNA repair (GO:0006281) |
| • double-strand break repair (GO:0006302) | • cellular response to DNA damage stimulus (GO:0006974) |
| • membrane (GO:0016020) | • protein auto-ADP-ribosylation (GO:0070213) |
Pathways
• DNA repair (Base excision repair
• Single-strand break repair)
• Apoptosis
• Telomere maintenance
• Chromatin remodeling
• PARP inhibitor response pathway
Protein Summary
PARP2 is a 583-amino acid protein with a molecular weight of approximately 66 kDa. It contains an N-terminal DNA-binding domain, a central automodification domain, and a C-terminal catalytic domain that transfers ADP-ribose from NAD+ to target proteins. PARP2 is activated by DNA strand breaks and plays a critical role in base excision repair and single-strand break repair. It also participates in transcriptional regulation and mitotic progression. PARP2 shares functional redundancy with PARP1 but has distinct roles in certain cellular contexts.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARP2 Knockout HEK293 Cell Line | EDJ-KQ3786 | Human | 10038 | Details Get a Quote |
| PARP2 Knockout A-549 Cell Line | EDJ-KQ18149 | Human | 10038 | Details Get a Quote |
| PARP2 Knockout HeLa Cell Line | EDJ-KQ24530 | Human | 10038 | Details Get a Quote |
| PARP2 Knockout HCT 116 Cell Line | EDJ-KQ25888 | Human | 10038 | Details Get a Quote |
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