PARP10 (Poly(ADP-Ribose) Polymerase Family Member 10): A Multifunctional ADP-Ribosyltransferase in DNA Repair, Inflammation, and Cancer
Comprehensive gene card, expression, mutations, and disease associations for PARP10, a mono-ADP-ribosyltransferase with roles in stress responses and tumor suppression.
Gene Information Card
| Symbol | PARP10 |
|---|---|
| Full Name | Poly(ADP-ribose) polymerase family member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q24.3 (GRCh38: 8:144,106,000-144,115,000) |
| NCBI Gene ID | 84875 ncbi.nlm.nih.gov/gene/84875 |
| Ensembl ID | ENSG00000178605 |
| UniProt ID | Q53GL7 |
| OMIM ID | 609725 |
| HGNC ID | 25994 |
| Aliases | ARTD10, FLJ14464, MGC33446 |
Description
PARP10 (Poly(ADP-ribose) polymerase family member 10) encodes a mono-ADP-ribosyltransferase that catalyzes the transfer of ADP-ribose from NAD+ to target proteins, modulating their function. It contains a macrodomain that binds ADP-ribose and a ubiquitin-binding zinc finger, linking it to DNA damage response, transcriptional regulation, and stress signaling. PARP10 is implicated in cell proliferation, apoptosis, and inflammatory responses, and is considered a tumor suppressor in certain contexts.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Loss of PARP10 expression or function may impair DNA repair and promote genomic instability, contributing to tumorigenesis. PARP10 also interacts with MYC and NF-κB pathways. | COSMIC: somatic mutations in various cancers; PubMed studies (e.g., Yu et al., 2019) show reduced expression in hepatocellular carcinoma. |
| Inflammatory diseases | PARP10 regulates NF-κB signaling and pro-inflammatory cytokine production; dysregulation may exacerbate inflammation. | Experimental studies (e.g., Verheugd et al., 2013) demonstrate PARP10's role in NF-κB activation. |
| Viral infection | PARP10 is targeted by viral proteases (e.g., from alphaviruses) to counteract host antiviral responses. | Studies on chikungunya virus (e.g., Eckei et al., 2017) show PARP10 cleavage. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 20.1 | High |
| Kidney | 15.3 | Medium |
| Liver | 12.8 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | Embryonic kidney; commonly used for PARP10 studies |
| HeLa | 12.3 | Cervical cancer; moderate expression |
| HepG2 | 10.1 | Liver cancer; reduced expression compared to normal liver |
| A549 | 7.8 | Lung carcinoma; low expression |
| MCF7 | 5.4 | Breast cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Ter) | Nonsense | 0.01% (gnomAD) | Truncated protein lacking catalytic domain; likely loss of function |
| c.1567G>A (p.Gly523Arg) | Missense | 0.02% (gnomAD) | Potential impact on substrate binding; functional studies not yet conclusive |
| c.2101_2102insA (p.Thr701AsnfsTer5) | Frameshift | 0.005% (gnomAD) | Premature stop; loss of function |
| c.2788C>T (p.Arg930Cys) | Missense | 0.03% (gnomAD) | Located in macrodomain; may affect ADP-ribose binding |
Mutation functional classification
Loss of Function (LOF)
Nonsense, frameshift, and splice-site mutations that lead to truncated or absent protein are classified as loss-of-function, impairing PARP10's catalytic activity and cellular functions.
Gain of Function (GOF)
No clear gain-of-function mutations have been reported; most variants are loss-of-function or neutral.
Dominant Negative (DN)
Some missense mutations in the catalytic domain may act in a dominant-negative manner by competing with wild-type protein, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
Pathways
• DNA damage response (DDR)
• NF-kappaB signaling
• Apoptosis
• Cellular response to stress
Protein Summary
PARP10 is a 1025-amino-acid protein with a molecular weight of ~112 kDa. It contains an N-terminal RNA recognition motif (RRM), a central catalytic ADP-ribosyltransferase domain, a macrodomain, and a C-terminal zinc finger. It localizes to both nucleus and cytoplasm and is involved in mono-ADP-ribosylation of target proteins, including itself (auto-modification). PARP10 interacts with PCNA, p53, and MYC, and plays roles in DNA replication stress response, cell cycle regulation, and apoptosis. Its expression is often downregulated in tumors, suggesting a tumor suppressor role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARP10 Knockout HEK293 Cell Line | EDJ-KQ9460 | Human | 84875 | Details Get a Quote |
| PARP10 Knockout HeLa Cell Line | EDJ-KQ37401 | Human | 84875 | Details Get a Quote |
| PARP10 Knockout A-549 Cell Line | EDJ-KQ66174 | Human | 84875 | Details Get a Quote |
| PARP10 Knockout HCT 116 Cell Line | EDJ-KQ74601 | Human | 84875 | Details Get a Quote |
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