OVCA2
OVCA2 Serine Hydrolase Domain Containing
Gene Information Card
| Symbol | OVCA2 |
|---|---|
| Full Name | OVCA2 Serine Hydrolase Domain Containing |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 124626 ncbi.nlm.nih.gov/gene/124626 |
| Ensembl ID | ENSG00000184979 |
| UniProt ID | Q8N4S6 |
| OMIM ID | 608543 |
| HGNC ID | 25591 |
| Aliases | OVCA2, OVCA2 serine hydrolase domain containing |
Description
OVCA2 is a protein-coding gene located on chromosome 17p13.3. It encodes a serine hydrolase domain-containing protein. The gene is frequently deleted or downregulated in ovarian cancer, suggesting a potential tumor suppressor role. OVCA2 is also implicated in other cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian cancer | Loss of heterozygosity and reduced expression of OVCA2 are observed in ovarian tumors, suggesting a tumor suppressor function. | PMID: 10655553 |
| Breast cancer | OVCA2 expression is decreased in breast cancer cell lines and primary tumors, potentially contributing to tumorigenesis. | PMID: 12460918 |
| Lung cancer | Reduced OVCA2 expression has been reported in non-small cell lung cancer, correlating with poor prognosis. | PMID: 17363564 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Ovary | 3.2 | Low |
| Breast | 2.8 | Low |
| Lung | 4.1 | Medium |
| Brain | 1.5 | Not detected |
| Heart | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 2.5 | Cervical cancer cell line |
| MCF7 | 1.8 | Breast cancer cell line |
| A549 | 3.0 | Lung cancer cell line |
| OVCAR3 | 1.2 | Ovarian cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional effect |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations and deletions leading to reduced OVCA2 expression are associated with loss of tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • serine hydrolase activity | • hydrolase activity |
| • protein binding |
Pathways
• No specific pathways are currently curated for OVCA2.
Protein Summary
The OVCA2 protein contains a serine hydrolase domain, suggesting it may function as a hydrolase enzyme. Its exact biochemical role is not fully characterized, but it is thought to participate in cellular processes relevant to tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OVCA2 Knockout HEK293 Cell Line | EDJ-KQ8616 | Human | 124641 | Details Get a Quote |
| OVCA2 Knockout A-549 Cell Line | EDJ-KQ34757 | Human | 124641 | Details Get a Quote |
| OVCA2 Knockout HCT 116 Cell Line | EDJ-KQ34758 | Human | 124641 | Details Get a Quote |
| OVCA2 Knockout HeLa Cell Line | EDJ-KQ34759 | Human | 124641 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
