OSGIN2
Oxidative Stress Induced Growth Inhibitor Family Member 2
Gene Information Card
| Symbol | OSGIN2 |
|---|---|
| Full Name | Oxidative Stress Induced Growth Inhibitor Family Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q21.3 |
| NCBI Gene ID | 734 ncbi.nlm.nih.gov/gene/734 |
| Ensembl ID | ENSG00000164741 |
| UniProt ID | Q9H1E3 |
| OMIM ID | 608204 |
| HGNC ID | 30092 |
| Aliases | OKL38, HSPC126, bA550O6.1 |
Description
OSGIN2 (oxidative stress induced growth inhibitor family member 2) is a protein-coding gene located on chromosome 8q21.3. It encodes a protein that is induced by oxidative stress and functions as a growth inhibitor, playing roles in apoptosis and cell cycle regulation. The gene is also known as OKL38 and HSPC126.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Downregulation of OSGIN2 may contribute to tumor progression; loss of expression associated with poor prognosis. | ClinVar, COSMIC |
| Hepatocellular carcinoma | Reduced OSGIN2 expression linked to increased cell proliferation and resistance to apoptosis. | NCBI Gene, PubMed |
| Oxidative stress-related disorders | OSGIN2 is induced by reactive oxygen species and may protect against oxidative damage. | UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Low |
| Heart | 6.1 | Low |
| Brain | 4.5 | Low |
| Lung | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HEK293 | 7.2 | Embryonic kidney cells |
| A549 | 4.1 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Unknown effect |
| c.245C>T | Nonsense | 0.005% | Predicted loss of function |
| c.678_679insA | Frameshift | 0.002% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in OSGIN2 are predicted to cause loss of function, potentially reducing growth inhibitory activity.
Gain of Function (GOF)
No gain-of-function mutations reported for OSGIN2.
Dominant Negative (DN)
No dominant-negative mutations reported for OSGIN2.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • negative regulation of cell growth |
| • response to oxidative stress | • protein binding |
Pathways
• p53 signaling pathway
• Apoptosis
Protein Summary
The OSGIN2 protein (UniProt Q9H1E3) is a 36 kDa protein induced by oxidative stress. It localizes to the cytoplasm and nucleus, and its expression is associated with growth inhibition and apoptosis. The protein contains a conserved domain of unknown function (DUF) and is involved in cellular stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OSGIN2 Knockout HEK293 Cell Line | EDJ-KQ4163 | Human | 734 | Details Get a Quote |
| OSGIN2 Knockout A-549 Cell Line | EDJ-KQ26605 | Human | 734 | Details Get a Quote |
| OSGIN2 Knockout HCT 116 Cell Line | EDJ-KQ26606 | Human | 734 | Details Get a Quote |
| OSGIN2 Knockout HeLa Cell Line | EDJ-KQ26607 | Human | 734 | Details Get a Quote |
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