OR5I1
Olfactory Receptor Family 5 Subfamily I Member 1
Gene Information Card
| Symbol | OR5I1 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily I Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 219970 ncbi.nlm.nih.gov/gene/219970 |
| Ensembl ID | ENSG00000196352 |
| UniProt ID | Q8NGX3 |
| OMIM ID | 618456 |
| HGNC ID | 8342 |
| Aliases | OR5I1P, OR11-107 |
Description
OR5I1 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) superfamily. These receptors are expressed in olfactory sensory neurons and mediate detection of odorants. OR5I1 is a member of the olfactory receptor family 5, subfamily I, and is located on chromosome 11q12.1. The protein is involved in chemosensory perception and signal transduction via the cAMP pathway.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line expression data available | N/A | N/A |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants
Gain of Function (GOF)
No documented gain-of-function variants
Dominant Negative (DN)
No documented dominant-negative variants
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR5I1 is a 312-amino acid olfactory receptor with seven transmembrane domains, typical of GPCRs. It is predicted to bind odorant molecules and activate G proteins, initiating a signaling cascade that leads to neuronal depolarization. No functional studies have been published for this specific receptor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5I1 Knockout HEK293 Cell Line | EDJ-KQ7172 | Human | 10798 | Details Get a Quote |
| OR5I1 Knockout HeLa Cell Line | EDJ-KQ55486 | Human | 10798 | Details Get a Quote |
| OR5I1 Knockout A-549 Cell Line | EDJ-KQ63976 | Human | 10798 | Details Get a Quote |
| OR5I1 Knockout HCT 116 Cell Line | EDJ-KQ72428 | Human | 10798 | Details Get a Quote |
