OR1C1: Olfactory Receptor Family 1 Subfamily C Member 1
A chemosensory G protein-coupled receptor involved in odorant detection and potential extraolfactory functions.
Gene Information Card
| Symbol | OR1C1 |
|---|---|
| Full Name | Olfactory Receptor Family 1 Subfamily C Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q44 |
| NCBI Gene ID | 26189 ncbi.nlm.nih.gov/gene/26189 |
| Ensembl ID | ENSG00000184922 |
| UniProt ID | Q8NGR6 |
| OMIM ID | 618060 |
| HGNC ID | 8195 |
| Aliases | OR1-42, OR1C1P, OR1C1Q, OR1C1R, OR1C1S, OR1C1T, OR1C1U, OR1C1V, OR1C1W, OR1C1X, OR1C1Y, OR1C1Z |
Description
OR1C1 encodes a member of the olfactory receptor family of G protein-coupled receptors (GPCRs). Olfactory receptors are primarily expressed in the olfactory epithelium and are responsible for detecting odorants, initiating a neuronal response that triggers the perception of smell. OR1C1 may also have extraolfactory roles in other tissues, such as the respiratory tract, skin, and reproductive organs, where it could mediate chemosensory functions. The gene is located on chromosome 1q44 and is part of a large olfactory receptor gene cluster.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| olfactory mucosa | 0.0 | Not detected |
| testis | 0.0 | Not detected |
| skin | 0.0 | Not detected |
| lung | 0.0 | Not detected |
| kidney | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HeLa | 0.0 | Not detected |
| A549 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function variants have been clinically characterized for OR1C1.
Gain of Function (GOF)
No gain-of-function variants have been reported.
Dominant Negative (DN)
No dominant-negative effects have been described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling
Protein Summary
OR1C1 is a 312-amino acid olfactory receptor with a typical GPCR structure, including seven transmembrane domains. It is predicted to localize to the plasma membrane and function via G protein-mediated signaling, primarily in olfactory sensory neurons. The protein sequence is highly conserved among primates, suggesting a role in odorant recognition.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR1C1 Knockout HEK293 Cell Line | EDJ-KQ8445 | Human | 26188 | Details Get a Quote |
| OR1C1 Knockout HeLa Cell Line | EDJ-KQ55892 | Human | 26188 | Details Get a Quote |
| OR1C1 Knockout A-549 Cell Line | EDJ-KQ64382 | Human | 26188 | Details Get a Quote |
| OR1C1 Knockout HCT 116 Cell Line | EDJ-KQ72833 | Human | 26188 | Details Get a Quote |
