OLIG1: Oligodendrocyte Transcription Factor 1
Key regulator of oligodendrocyte development and central nervous system myelination
Gene Information Card
| Symbol | OLIG1 |
|---|---|
| Full Name | Oligodendrocyte transcription factor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 21q22.11 |
| NCBI Gene ID | 116448 ncbi.nlm.nih.gov/gene/116448 |
| Ensembl ID | ENSG00000184221 |
| UniProt ID | Q8TAK6 |
| OMIM ID | 606385 |
| HGNC ID | 8056 |
| Aliases | BHLHB6, bHLHe20, OLIGO1 |
Description
OLIG1 encodes a basic helix-loop-helix (bHLH) transcription factor essential for the specification and differentiation of oligodendrocytes in the central nervous system. It regulates genes involved in myelination and is expressed in oligodendrocyte lineage cells. OLIG1 is also implicated in neural development and certain brain tumors, particularly gliomas.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | OLIG1 expression is frequently upregulated in gliomas, contributing to tumor cell proliferation and differentiation arrest. | PMID: 17634366 |
| Oligodendroglioma | OLIG1 is a diagnostic marker for oligodendroglial tumors, with high expression correlating with oligodendrocyte lineage. | PMID: 11526406 |
| Multiple sclerosis | OLIG1+ oligodendrocyte precursor cells are present in demyelinated lesions but fail to mature, suggesting impaired differentiation. | PMID: 12130774 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Spinal cord | 8.3 | Medium |
| Testis | 0.2 | Low |
| Heart | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 0.5 | Neuroblastoma cell line |
| U87MG | 2.1 | Glioblastoma cell line |
| HEK293 | 0.0 | No detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional effect |
| c.100C>T | synonymous | <0.1% | No known effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in human disease.
Gain of Function (GOF)
Overexpression in gliomas suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Oligodendrocyte specification and differentiation
• Notch signaling pathway
• Wnt signaling pathway
Protein Summary
OLIG1 is a 303-amino acid protein containing a bHLH domain that mediates DNA binding and dimerization. It forms heterodimers with other bHLH factors to regulate transcription of genes critical for oligodendrocyte maturation and myelin production. The protein localizes to the nucleus and is highly expressed in developing and adult white matter.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OLIG1 Knockout HEK293 Cell Line | EDJ-KQ3768 | Human | 116448 | Details Get a Quote |
| OLIG1 Knockout HeLa Cell Line | EDJ-KQ57989 | Human | 116448 | Details Get a Quote |
| OLIG1 Knockout A-549 Cell Line | EDJ-KQ66475 | Human | 116448 | Details Get a Quote |
| OLIG1 Knockout HCT 116 Cell Line | EDJ-KQ74898 | Human | 116448 | Details Get a Quote |
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